公开(公告)号：US12112792B2

公开(公告)日：2024-10-08

申请号：US17712935

申请日：2022-04-04

申请人： Micron Technology, Inc.

发明人： Glen E. Hush ,  Sean S. Eilert ,  Aliasger T. Zaidy ,  Kunal R. Parekh

IPC分类号： H01L23/00 ,  G06F3/06 ,  G06F13/16 ,  G06F13/28 ,  G11C7/08 ,  G11C7/10 ,  G11C11/408 ,  G11C11/4091 ,  G11C11/4093 ,  G11C11/4096 ,  G16B30/00 ,  G16B50/10 ,  H01L21/66 ,  H01L21/78 ,  H01L25/00 ,  H01L25/065 ,  H01L25/18

CPC分类号： G11C11/4093 ,  G06F3/0656 ,  G06F13/1673 ,  G06F13/28 ,  G11C7/08 ,  G11C7/1039 ,  G11C11/4087 ,  G11C11/4091 ,  G11C11/4096 ,  G16B30/00 ,  G16B50/10 ,  H01L21/78 ,  H01L22/12 ,  H01L24/08 ,  H01L24/48 ,  H01L24/80 ,  H01L25/0652 ,  H01L25/0657 ,  H01L25/18 ,  H01L25/50 ,  G06F2213/28 ,  H01L24/16 ,  H01L2224/0801 ,  H01L2224/08145 ,  H01L2224/1601 ,  H01L2224/16221 ,  H01L2224/48091 ,  H01L2224/48145 ,  H01L2224/48221 ,  H01L2224/80895 ,  H01L2224/80896 ,  H01L2225/06517 ,  H01L2225/06524 ,  H01L2225/06527 ,  H01L2225/06541 ,  H01L2225/06565 ,  H01L2225/06589 ,  H01L2924/1431 ,  H01L2924/14335 ,  H01L2924/1436

摘要： A memory device includes an array of memory cells configured on a die or chip and coupled to sense lines and access lines of the die or chip and a respective sense amplifier configured on the die or chip coupled to each of the sense lines. Each of a plurality of subsets of the sense lines is coupled to a respective local input/output (I/O) line on the die or chip for communication of data on the die or chip and a respective transceiver associated with the respective local I/O line, the respective transceiver configured to enable communication of the data to one or more device off the die or chip.

公开(公告)号：US12065699B2

公开(公告)日：2024-08-20

申请号：US16085455

申请日：2017-03-14

申请人： Repertoire Genesis Incorporation

发明人： Tadasu Shini ,  Ryuji Suzuki

IPC分类号： C12Q1/6881 ,  C07K7/04 ,  G01N33/574 ,  G01N33/68 ,  G16B5/00 ,  G16B5/20 ,  G16B15/00 ,  G16B15/30 ,  G16B20/00 ,  G16B20/20 ,  G16B20/30 ,  G16B25/10 ,  G16B30/00 ,  G16B30/10 ,  G16B40/00 ,  G16B45/00 ,  G16B50/10 ,  G16B50/20

CPC分类号： C12Q1/6881 ,  C07K7/04 ,  G01N33/574 ,  G01N33/6878 ,  G16B5/00 ,  G16B5/20 ,  G16B15/00 ,  G16B15/30 ,  G16B20/00 ,  G16B20/20 ,  G16B20/30 ,  G16B25/10 ,  G16B30/00 ,  G16B30/10 ,  G16B40/00 ,  G16B45/00 ,  G16B50/10 ,  G16B50/20 ,  C12Q2600/156

摘要： The present invention provides a method for producing a peptide for the treatment (in particular, immunotherapy), monitoring, or diagnosis of a disease in a subject. This method is achieved by obtaining information pertaining to a genome read, for example an exome read, of the subject and a mutation thereof, and, as necessary, information regarding the RNA sequence of the subject and information regarding the MHC type of the subject, analyzing an epitope related to the mutation on the basis of the information pertaining to the genome read (for example, the exome read) and the mutation, arbitrary information from the RNA sequence, the MHC type information, and information regarding the disease, and producing a peptide, as necessary, on the basis of information regarding the epitope.

公开(公告)号：US12050228B2

公开(公告)日：2024-07-30

申请号：US17097491

申请日：2020-11-13

申请人： Metabolon, Inc.

发明人： Adam D. Kennedy ,  Matthew W. Mitchell ,  Meredith V. Brown ,  Kay A. Lawton ,  Shaun Lonergan ,  Jacob Edward Wulff

IPC分类号： G01N35/00 ,  G01N33/48 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/66 ,  G01N33/68 ,  G01N33/92 ,  G16B40/10 ,  G16B50/00 ,  G16B50/10 ,  G16B50/30 ,  G16B99/00

CPC分类号： G01N35/00613 ,  G01N33/48 ,  G01N33/492 ,  G01N33/50 ,  G01N33/5308 ,  G01N33/66 ,  G01N33/68 ,  G01N33/92 ,  G16B40/10 ,  G16B50/00 ,  G16B50/10 ,  G16B50/30 ,  G16B99/00 ,  G01N2560/00 ,  G01N2570/00

摘要： A method of assessing the quality of a biological sample while maintaining the viability of the biological sample for intended use analysis is described herein. The method includes analyzing a biological sample obtained from a subject for an intended use, assessing the quality of the biological sample using one or more biomarkers of sample quality, and simultaneously performing intended use analysis on the same sample. Assessing the quality of the sample can include assessing compliance with sample handling protocols and assessing subject compliance.

公开(公告)号：US12040054B2

公开(公告)日：2024-07-16

申请号：US15931009

申请日：2020-05-13

申请人： Ancestry.com DNA, LLC

发明人： Shiya Song ,  Keith D. Noto ,  Yong Wang

IPC分类号： G16B5/20 ,  C12Q1/6827 ,  G06F17/18 ,  G06N5/01 ,  G06N7/01 ,  G16B5/00 ,  G16B20/20 ,  G16B20/40 ,  G16B30/00 ,  G16B40/00 ,  G16B50/10 ,  G16H10/40 ,  G16H10/60 ,  G06N20/00

CPC分类号： G16B5/20 ,  C12Q1/6827 ,  G06N5/01 ,  G06N7/01 ,  G16B5/00 ,  G16B20/20 ,  G16B20/40 ,  G16B30/00 ,  G16B40/00 ,  G16B50/10 ,  G16H10/40 ,  G16H10/60 ,  G06F17/18 ,  G06N20/00

摘要： An input genotype is divided into a plurality of windows, each including a sequence of SNPs. For each window, a diploid HMM is computed based on genotypes and/or phased haplotypes to determine a probability of a haplotype sequence being associated with a particular label. For example, the diploid HMM for a window is used to determine the emission probability that the window corresponds to a set of labels. An inter-window HMM, with a set of states for each window, is computed. Labels are assigned to the input genotype based on the inter-window HMM. Upper and lower bounds are estimated to produce a range of likely percentage values an input can be assigned to a given label. Confidence values are determined indicating a likelihood that an individual inherits DNA from a certain population. Maps are generated with polygons representing regions where a measure of ethnicity of population falls within specific ranges.

公开(公告)号：US20240203534A1

公开(公告)日：2024-06-20

申请号：US18391014

申请日：2023-12-20

申请人： Illumina, Inc.

发明人： Andrew Warren ,  Benjamin Rinvelt ,  Max Arseneault

IPC分类号： G16B50/10 ,  G16B30/00

CPC分类号： G16B50/10 ,  G16B30/00

摘要： Systems, methods, and apparatus are described herein for aggregating genome data into bins with summary data at various levels. As described herein, a computing device may be configured to receive genome data associated with a genome. The computing device may be configured to generate an aggregate file using the received genome data. The aggregate file may include a plurality of bins at a plurality of depths. The computing device may be configured to determine summary data for respective reads associated with one or more respective portions of the genome covered by respective bins of the plurality of bins. The computing device may be configured to store the summary data for the respective reads in respective bins of the plurality of bins. The computing device may be configured to display a portion of the summary data in response to a selection of a genomic region by a user.

公开(公告)号：US20240112759A1

公开(公告)日：2024-04-04

申请号：US17958127

申请日：2022-09-30

申请人： Scinapsis Analytics Inc., dba BenchSci

发明人： Tom LEUNG ,  Casandra Savitri MANGROO ,  Luigi GENTILE

IPC分类号： G16B50/30 ,  G16B45/00 ,  G16B50/10

CPC分类号： G16B50/30 ,  G16B45/00 ,  G16B50/10

摘要： A method implements an experiment architect. The method includes receiving an entity identifier; searching a plurality of result graphs using the entity identifier to identify a file comprising content corresponding to the entity identifier; and presenting a figure from the file in response to identifying the file.

公开(公告)号：US20240087687A1

公开(公告)日：2024-03-14

申请号：US18463902

申请日：2023-09-08

申请人： Truveta, Inc.

发明人： Cezary Antoni Marcjan ,  Mariyam Amir ,  Murchana Baruah ,  Mahsa Eslamialishah ,  Sina Ehsani ,  Alireza Bahramali ,  Sadra Naddaf-Shargh ,  Saman Zarandioon

IPC分类号： G16B50/10 ,  G06F16/31 ,  G16B50/20

CPC分类号： G16B50/10 ,  G06F16/322 ,  G16B50/20

摘要： Systems and methods for aligning ontologies, such as a medical or related ontologies, are disclosed. Initially, ontology specifications are received, such as ontologies comprising a root node and a plurality of child nodes. Each node is assigned at least one synthetic identifier corresponding to its path(s) to the root node. In some cases, nodes may be clustered using one or more clustering algorithms. A translation model is pre-trained by applying one or more masked language models to the ontologies and the synthetic identifiers. Subsequently, each ontology is augmented by identifying nodes in different ontologies that match and assigning label and/or other details across different ontologies. The translation model can then be fine-tuned using the augmented data. The fine-tuned translation model is then used to identify corresponding nodes in target ontologies in response to translation requests.

公开(公告)号：US11734822B2

公开(公告)日：2023-08-22

申请号：US17871665

申请日：2022-07-22

申请人： Thread Robotics Inc.

发明人： Gurjeet Singh ,  Kiran Joshi ,  Sahil Gupta

IPC分类号： G06T7/00 ,  G06V20/69 ,  G06T7/20 ,  G06V20/40 ,  G16B40/00 ,  G16B5/20 ,  G06V10/764 ,  G16B50/10

CPC分类号： G06T7/0012 ,  G06T7/20 ,  G06V10/764 ,  G06V20/46 ,  G06V20/69 ,  G16B5/20 ,  G16B40/00 ,  G06T2207/30024 ,  G16B50/10

摘要： In variants, a method for automated gamete selection can include: sampling a video of a scene having a plurality of gametes, tracking each gamete across successive images, and determining attribute values for a gamete, and selecting the gamete. The attribute values can be determined using a model trained to predict the attribute values for the gamete based on a video.

公开(公告)号：US20230050961A1

公开(公告)日：2023-02-16

申请号：US17885242

申请日：2022-08-10

申请人： Micron Technology, Inc.

发明人： Sean S. Eilert ,  Kunal R. Parekh ,  Aliasger T. Zaidy ,  Glen E. Hush

IPC分类号： G16B50/10 ,  H01L25/18 ,  G11C11/4093 ,  G11C11/4096 ,  G16B30/00 ,  G06F13/28

摘要： A wafer-on-wafer formed memory and logic device can enable high bandwidth transmission of data directly between a memory die and a logic die. A logic die that is bonded to a memory die via a wafer-on-wafer bonding process can receive signals indicative of a genetic sequence from the memory die and through a wafer-on-wafer bond. The logic die can also perform a genome annotation lotic operation to attach biological information to the genetic sequence. An annotated genetic sequence can be provided as an output.

公开(公告)号：US11573239B2

公开(公告)日：2023-02-07

申请号：US16037949

申请日：2018-07-17

申请人： BIOINFORMATICS SOLUTIONS INC.

发明人： Baozhen Shan ,  Ngoc Hieu Tran ,  Ming Li ,  Lei Xin ,  Xianglilan Zhang

IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/68 ,  G06F17/16 ,  G16B20/00 ,  G16B40/00 ,  G16B50/00 ,  G16B30/20 ,  G16B40/10 ,  G16B40/20 ,  G16B50/20 ,  G16B50/10

摘要： The present systems and methods introduce deep learning to de novo peptide sequencing from tandem mass spectrometry data. The systems and methods achieve improvements in sequencing accuracy over existing systems and methods and enables complete assembly of novel protein sequences without assisting databases. The present systems and methods are re-trainable to adapt to new sources of data and provides a complete end-to-end training and prediction solution, which is advantageous given the growing massive amount of data. The systems and methods combine deep learning and dynamic programming to solve optimization problems.