公开(公告)号：US20180143194A1

公开(公告)日：2018-05-24

申请号：US15563667

申请日：2016-04-04

Applicant: THE UNIVERSITY OF ROCHESTER ,  EMORY UNIVERSITY

Inventor： John Linforth DAISS ,  Edward M. SCHWARZ ,  Kohei NISHITANI ,  Sandeep SOIN ,  Frances Eun-Hyung LEE

IPC: G01N33/569 ,  G01N33/50 ,  G01N33/536 ,  C07K16/12

CPC classification number: G01N33/56938 ,  C07K16/1271 ,  C07K2317/14 ,  G01N33/5091 ,  G01N33/536

Abstract: Provided herein are compositions and methods for detecting and/or diagnosing a Staphylococcus aureus (S. aureus) infection in a subject. It is a surprising finding of the present invention that an S. aureus infection may be detected by using one or more antigens selected from the group consisting of an IsdA antigen, IsdB antigen, CHIPS antigen, and a SCIN antigen. In some embodiments, these S. aureus antigens are used to detect antibodies secreted by the plasmablasts from the subject.