专利检索 ap:("THERAVECTYS" OR "INSTITUT CURIE" OR "CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE" OR "UNIVERSITE PIERRE ET MARIE CURIE" OR "INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)") AND inv:"Sophie Agaugue" 第 1 页

1.

发明授权
Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule 有权

公开(公告)号：US10752668B2

公开(公告)日：2020-08-25

申请号：US15327517

申请日：2015-07-24

申请人： THERAVECTYS , INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PIERRE ET MARIE CURIE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Sophie Agaugue , Lorenzo Tibaldi , Klervi Even-Desrumaux , Dmitry Trubetskoy , Franck Perez , Sebastian Amigorena , Cécile Bauche

IPC分类号： C07K16/30 , G01N33/574 , C07K16/28 , C07K14/705 , C12N5/0783 , A61K35/17 , C07K16/00 , A61K38/00

摘要： The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors.