公开(公告)号：US20180303976A1

公开(公告)日：2018-10-25

申请号：US15765309

申请日：2016-10-03

Applicant: THOMAS JEFFERSON UNIVERSITY

Inventor： Noreen J. Hickok ,  Constantinos Ketonis ,  Javad Parvizi ,  Irving M. Shapiro ,  Christopher S. Adams ,  John A. Abraham

IPC: A61L27/54 ,  A61L27/36

CPC classification number: A61L27/54 ,  A61L27/3608 ,  A61L27/365 ,  A61L2300/406 ,  A61L2430/02

Abstract: A functionalized tissue having covalently bound antibiotics and methods for producing the functionalized tissue having bound antibiotics comprising; providing a tissue having a sufficient number of primary amine groups on the tissue; coupling and deprotecting one or more F-moc AEEA linkers using HATU chemistry to the primary amine groups; and coupling an antibiotic to said AEEA linkers using HATU chemistry.