公开(公告)号：US20180303976A1

公开(公告)日：2018-10-25

申请号：US15765309

申请日：2016-10-03

Applicant: THOMAS JEFFERSON UNIVERSITY

Inventor： Noreen J. Hickok ,  Constantinos Ketonis ,  Javad Parvizi ,  Irving M. Shapiro ,  Christopher S. Adams ,  John A. Abraham

IPC: A61L27/54 ,  A61L27/36

CPC classification number: A61L27/54 ,  A61L27/3608 ,  A61L27/365 ,  A61L2300/406 ,  A61L2430/02

Abstract: A functionalized tissue having covalently bound antibiotics and methods for producing the functionalized tissue having bound antibiotics comprising; providing a tissue having a sufficient number of primary amine groups on the tissue; coupling and deprotecting one or more F-moc AEEA linkers using HATU chemistry to the primary amine groups; and coupling an antibiotic to said AEEA linkers using HATU chemistry.

公开(公告)号：US20170056565A1

公开(公告)日：2017-03-02

申请号：US15250020

申请日：2016-08-29

Applicant: Thomas Jefferson University ,  Drexel University

Inventor： Christopher K. Kepler ,  Alex Michael Sevit ,  Steven Michael Kurtz ,  Noreen J. Hickok ,  Flemming Forsberg ,  John R. Eisenbrey

IPC: A61L31/14 ,  A61B17/70 ,  A61M37/00 ,  A61L31/06 ,  A61L31/16

CPC classification number: A61L31/14 ,  A61B17/7061 ,  A61B17/7067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  C08L71/12 ,  C08L67/04

Abstract: An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is sealed with a biocompatible pressure responsive coating; wherein the biocompatible coating is stable for at least 7-day post implantation into a body, and can be mechanically ruptured by application of an exterior pressure generating force.

Abstract translation: 一种具有由聚合物材料形成的护套的可植入医疗装置，其中所述护套形成附接到所述可植入医疗装置或其周围的储存器，并且其中所述储存器用生物相容性压力响应涂层密封; 其中所述生物相容性涂层在植入体内至少7天后是稳定的，并且可以通过施加外部压力产生力而机械破裂。