公开(公告)号：US20160303107A1

公开(公告)日：2016-10-20

申请号：US15103234

申请日：2014-12-09

Applicant: THOMAS JEFFERSON UNIVERSITY

Inventor： Davide TROTTI ,  Piera PASINELLI ,  Michael R. JABLONSKI

IPC: A61K31/473 ,  A61K31/428

CPC classification number: A61K31/473 ,  A61K31/428 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/55 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ABC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurodegenerative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.

Abstract translation: 本发明提供了治疗或改善哺乳动物神经变性疾病的方法，所述方法包括向哺乳动物施用治疗有效量的神经变性疾病药物，其中所述药物是ABC转运蛋白抑制剂的底物，其中所述哺乳动物是 进一步施用治疗有效量的ABC转运蛋白抑制剂，由此在哺乳动物中治疗神经变性疾病。 在某些实施方案中，神经变性疾病包括选自脊髓损伤，阿尔茨海默氏病，帕金森氏病，亨廷顿病，朊病毒病，肌萎缩性侧索硬化，tau病变和慢性创伤性脑病中的至少一种。