公开(公告)号：US20220098167A1

公开(公告)日：2022-03-31

申请号：US17547940

申请日：2021-12-10

Applicant: TMEM16A Limited

Inventor： Stephen COLLINGWOOD ,  Clive MCCARTHY ,  Duncan Alexander HAY ,  Jonathan David HARGRAVE ,  Albert MA ,  Thomas Beauregard SCHOFIELD ,  Matthew SMITH ,  Edward WALKER ,  Naomi WENT ,  Peter INGRAM ,  Christopher STIMSON ,  Someina KHOR

IPC: C07D401/06 ,  C07D235/08 ,  C07D405/06 ,  C07D413/10 ,  C07D405/12 ,  C07D263/56 ,  C07D231/56 ,  C07D471/04

Abstract: Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: wherein represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

公开(公告)号：US20220098164A1

公开(公告)日：2022-03-31

申请号：US17547967

申请日：2021-12-10

Applicant: TMEM16A Limited

Inventor： Stephen COLLINGWOOD ,  Jonathan David HARGRAVE ,  Duncan Alexander HAY ,  Edward WALKER

IPC: C07D333/36 ,  C07C233/07 ,  C07D213/56 ,  C07D213/127 ,  C07D213/72

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, A, Z1, Z2 and Y are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.