公开(公告)号：US11986480B2

公开(公告)日：2024-05-21

申请号：US16482994

申请日：2018-02-02

申请人： TOHOKU UNIVERSITY

发明人： Hirokazu Arimoto ,  Kaori Itto ,  Daiki Takahashi ,  Nobuo Cho ,  Hiroshi Nara ,  Kenichiro Shimokawa ,  Taiichi Ohra ,  Shigekazu Sasaki ,  Naoki Ishii

IPC分类号： C07D495/04 ,  A61K31/513 ,  A61K31/522 ,  A61K31/551

CPC分类号： A61K31/522 ,  A61K31/513 ,  A61K31/551 ,  C07D495/04

摘要： Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.