公开(公告)号：US20250073204A1

公开(公告)日：2025-03-06

申请号：US18950382

申请日：2024-11-18

Applicant: TONIX PHARMACEUTICALS HOLDING CORP

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

Abstract: The present invention relates to cyclobenzaprine analogs and amitryptilene analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US11517557B2

公开(公告)日：2022-12-06

申请号：US16630832

申请日：2018-07-13

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  C07C211/32 ,  C07D205/04 ,  A61K45/06 ,  A61K31/135

Abstract: The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US20220130500A1

公开(公告)日：2022-04-28

申请号：US17508182

申请日：2021-10-22

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMACEUTICALS INC.

Inventor： Seth Lederman ,  Philip B. Stark ,  Ben Vaughn

IPC: G16H10/20 ,  G06F17/18

Abstract: Systems and methods for an analysis of clinical trial data using randomization tests that honors the randomized design of the clinical trial are provided herein. In particular, a non-parametric analyzer implementing randomization tests and associated methods for analyzing clinical data is provided. The non-parametric analyzer receives clinical trial data comprising a data structure containing data corresponding to subjects in the clinical trial, where the subjects have been organized into treatment groups, including at least one control group. The non-parametric analyzer generates multiple treatment allocations of the data structure by reorganizing, at random, the subjects along with corresponding data to generate further groups. In some embodiments, the non-parametric analyzer determines the statistical significance based on an overall probability and the multiple allocations of the data structure. The overall probability may be generated via a combination analysis for comparing test statistics between groups of the data structure and the multiple allocations.

公开(公告)号：US20240165126A1

公开(公告)日：2024-05-23

申请号：US18282285

申请日：2022-03-15

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMA LIMITED

Inventor： Seth Lederman ,  Siobhan J. Fogarty

IPC: A61K31/554 ,  A61K9/20 ,  A61K31/485

CPC classification number: A61K31/554 ,  A61K9/2054 ,  A61K31/485

Abstract: A composition comprising tianeptine, pharmaceutically acceptable salts thereof or polymorphs of one or both and naloxone or a pharmaceutically acceptable salt thereof, methods of manufacturing the composition, and methods for preventing or treating major depressive disorder (MDD) or symptoms associated therewith comprising administering the composition to a subject in need or at risk thereof.

公开(公告)号：US20240024256A1

公开(公告)日：2024-01-25

申请号：US18265525

申请日：2021-12-07

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Gregory M. Sullivan

IPC: A61K31/135 ,  A61P25/00 ,  A61K9/00

CPC classification number: A61K31/135 ,  A61P25/00 ,  A61K9/006

Abstract: Methods for treating fibromyalgia and one or more of its associated symptoms of pain, sleep disturbance and/or fatigue comprising administering to a subject in need thereof, 5.6 mg cyclobenzaprine HCl per day in one or more dosage units by transmucosal administration, the cyclobenzaprine HCl being in a form of a eutectic, and the one or more dosage units further comprising a basifying agent.

公开(公告)号：US20240009146A1

公开(公告)日：2024-01-11

申请号：US18037815

申请日：2021-11-19

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Greg M. Sullivan

IPC: A61K31/137

CPC classification number: A61K31/137

Abstract: The present disclosure provides a method for treating alcohol use disorder (AUD) and associated symptoms to a subject in need thereof by administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The pharmaceutically acceptable salt comprises a cyclobenzaprine acid salt.

公开(公告)号：US20190185438A1

公开(公告)日：2019-06-20

申请号：US15833973

申请日：2017-12-06

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Bruce Daughtery

IPC: C07D265/30 ,  C07C57/15

CPC classification number: C07D265/30 ,  A61K31/5375 ,  C07B2200/13 ,  C07C57/15

Abstract: Disclosed herein are salts and polylmoprhs of (2S)-2-[(S)-(ethoxyphenoxy)phenylmethyl]morpholine (esreboxetine) as shown in Formula I: wherein an acid is selected from adipic, L-ascorbic, L-aspartic, fumaric, glycolic, hydrochloric, maleic, mucic, phosphoric, sulfuric, and thiocyanic acid.

公开(公告)号：US12156864B2

公开(公告)日：2024-12-03

申请号：US18075386

申请日：2022-12-05

Applicant: TONIX PHARMACEUTICALS HOLDING CORP

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

Abstract: The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US20230002741A1

公开(公告)日：2023-01-05

申请号：US17827320

申请日：2022-05-27

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMA LIMITED

Inventor： David Evans ,  Ryan Noyce ,  Seth Lederman

IPC: C12N7/00 ,  A61K39/275 ,  A61K39/12 ,  A61P31/20

Abstract: The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

公开(公告)号：US20210260182A1

公开(公告)日：2021-08-26

申请号：US17187678

申请日：2021-02-26

Applicant: Scott J. Goebel ,  David Evans ,  Ryan Noyce ,  Tonix Pharmaceuticals Holding Corp. ,  The Governors of the University of Alberta

Inventor： Seth Lederman ,  Scott J. Goebel ,  David Evans ,  Ryan Noyce

IPC: A61K39/215 ,  C12N7/00 ,  C12N15/85

Abstract: The invention relates in various aspects to a recombinant poxvirus comprising a nucleic acid encoding a SARS-CoV-2 virus protein, methods for producing such viruses and the use of such viruses. The recombinant poxviruses are well suited, among others, as protective virus vaccines against SARS-CoV-2 virus.