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公开(公告)号：US20180325821A1
公开(公告)日：2018-11-15
申请号：US15988501
申请日：2018-05-24
发明人： Barbara Freund , Jörg Heeren , Peter Nielsen , Antonella Carambia , Johannes Herkel , Oliver Bruns , Ansgar Lohse , Stefan Lüth , Horst Weller , Sunhild Salmen
IPC分类号： A61K9/14 , A61K49/18 , A61K9/107 , A61K39/00 , C12N5/0783 , A61K51/12 , A61K47/69 , A61K49/00 , A61K39/39 , A61K9/00
CPC分类号： A61K9/146 , A61K9/0019 , A61K9/1075 , A61K39/0008 , A61K39/39 , A61K47/6907 , A61K49/0067 , A61K49/1809 , A61K49/1857 , A61K51/1227 , A61K2039/55555 , C12N5/0637 , C12N2502/14
摘要： The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
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公开(公告)号：US10898436B2
公开(公告)日：2021-01-26
申请号：US15988501
申请日：2018-05-24
发明人： Barbara Freund , Jörg Heeren , Peter Nielsen , Antonella Carambia , Johannes Herkel , Oliver Bruns , Ansgar Lohse , Stefan Lüth , Horst Weller , Sunhild Salmen
IPC分类号： A61K39/395 , A61K9/14 , A61K47/69 , A61K9/107 , A61K49/00 , A61K49/18 , A61K51/12 , A61K39/00 , A61K39/39 , C12N5/0783 , A61K9/00
摘要： The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
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公开(公告)号：US10004689B2
公开(公告)日：2018-06-26
申请号：US13261883
申请日：2012-11-14
发明人： Barbara Freund , Jörg Heeren , Peter Nielsen , Antonella Carambia , Johannes Herkel , Oliver Bruns , Ansgar Lohse , Stefan Lüth , Horst Weller , Sunhild Salmen
IPC分类号： A61K9/14 , A61K9/107 , A61K49/00 , A61K49/18 , A61K51/12 , A61K39/00 , A61K39/39 , C12N5/0783 , A61K47/69 , A61K9/00
CPC分类号： A61K9/146 , A61K9/0019 , A61K9/1075 , A61K39/0008 , A61K39/39 , A61K47/6907 , A61K49/0067 , A61K49/1809 , A61K49/1857 , A61K51/1227 , A61K2039/55555 , C12N5/0637 , C12N2502/14
摘要： The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
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