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公开(公告)号：US10946181B2
公开(公告)日：2021-03-16
申请号：US16102427
申请日：2018-08-13
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato
Abstract: A plurality of projections in a transdermal administration device each include a columnar portion extending from a first surface of a substrate, and a tapered portion extending from a top of the columnar portion. A maximum angle of an apex of the tapered portion viewed in a direction parallel with the first surface is in a range of 10° or more and 30° or less, a ratio of a length from a proximal end to a distal end of the tapered portion to a length from a proximal end to a distal end of the projection as viewed in a direction perpendicular to the first surface is in a range of 0.45 or more and 0.75 or less, and a pitch (distance between centers of closest projections), viewed in a direction perpendicular to the first surface is in a range of 50 μm or more and 350 μm or less.
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公开(公告)号：US10525243B2
公开(公告)日：2020-01-07
申请号：US15217306
申请日：2016-07-22
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato
IPC: A61M37/00
Abstract: A microneedle unit includes a microneedle including a facing surface having at least one projection and a support surface opposite to the facing surface, a recessed container having a housing space between an opening and a bottom of the recessed container for housing the microneedle such that the microneedle has the facing surface facing outside of the recessed container through the opening, and an adhering structure having a first contact surface adhered to the bottom of the recessed container and a second contact surface adhered to the support surface of the microneedle. The recessed container is deformable such that the bottom is displaced in the pressing direction, that the at least one projection is displaced in the pressing direction on an outside of the housing space, and that a portion of the second contact surface positioned outside the support surface is pushed toward the outside of the housing space.
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公开(公告)号：US09675545B2
公开(公告)日：2017-06-13
申请号：US14959228
申请日：2015-12-04
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato
CPC classification number: A61K9/0021 , A61K8/0204 , A61K8/736 , A61K38/00 , A61K47/36 , A61K47/61 , A61K2800/91 , A61M2037/0046 , A61M2037/0053 , A61Q19/00
Abstract: An acicular body includes a support base, and a needle formed on the support base and containing a chitosan derivative.
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公开(公告)号：US10363406B2
公开(公告)日：2019-07-30
申请号：US14922970
申请日：2015-10-26
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato
Abstract: A method for producing an acicular body having a support base and an acicular protrusion on one surface of the support base includes supplying an acicular body-forming liquid, in which an acicular body-forming material is dissolved or dispersed in a solvent, to an intaglio plate having a recess corresponding to a protrusion, under a first pressure environment of not more than 0.05 MPa, changing the first pressure environment of the acicular body-forming liquid supplied to the intaglio plate to a second pressure environment of higher than 0.05 MPa, drying the acicular body-forming liquid supplied to the intaglio plate such that an acicular body is formed, and peeling the acicular body from the intaglio plate.
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公开(公告)号：US09849271B2
公开(公告)日：2017-12-26
申请号：US14470078
申请日：2014-08-27
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato , Takako Yamamoto , Yoshikazu Taroura
CPC classification number: A61M37/0015 , A61K9/0021 , A61K47/12 , A61K47/36 , A61M2037/0046 , A61M2037/0053 , B29C39/003 , B29C41/12 , B29K2005/00 , F04C2270/041
Abstract: A needle-shaped structure includes a needle-shaped projection and a support substrate supporting the projection wherein the projection contains at least a chitosan and an organic acid, places a low burden on a living body and is able to keep the microscopic form after puncture into the skin.
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Patent Agency Ranking
公开(公告)号：US10682504B2
公开(公告)日：2020-06-16
申请号：US15003366
申请日：2016-01-21
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato
Abstract: A microneedle includes a substrate, and projections which extend from a surface of the substrate. Each of the projections includes layers separated from each other in a direction in which the projection extends. The layers include a first layer which contains a polymer which is soluble in water and poorly soluble in oil and a second layer which contains a polymer that is soluble in oil. The first layer and the second layer are adjacent to each other and are formed in the order of the first layer and the second layer from the projection to the substrate.
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公开(公告)号：US10456504B2
公开(公告)日：2019-10-29
申请号：US15003457
申请日：2016-01-21
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato , Takako Yamamoto
Abstract: An acicular body includes a support plate having a brightness of 5.0 or less, and a needle disposed on the support plate. The needle includes a tip formed to pierce a skin and a light transmission area which is located in an area including the tip and has a total light transmittance of 20% or more.
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公开(公告)号：US10918845B2
公开(公告)日：2021-02-16
申请号：US15647540
申请日：2017-07-12
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato , Ichiro Takase
Abstract: A transdermal administration device including a first administration member including a first substrate and a first projection protruding from a first administration surface of the first substrate, and a second administration member including a second substrate and a second projection protruding from a second administration surface of the second substrate. The first substrate has an aperture, and the second substrate is positioned within the aperture when viewed in a direction perpendicular to the second administration surface.
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公开(公告)号：US10561831B2
公开(公告)日：2020-02-18
申请号：US15647598
申请日：2017-07-12
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroyuki Kato
Abstract: A transdermal administration device packaged body includes a transdermal administration device including an administration member housed in a container, the administration member having at least one projection protruding from a first surface of a substrate, and an outer package which houses the transdermal administration device and has a bag form including a front component and a rear component. The front component is positioned on a first surface side of the substrate, the rear component is positioned on a second surface side opposite to the first surface side of the substrate, and the front component has an opening member configured to be pulled open to open the outer package.
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公开(公告)号：US09919141B2
公开(公告)日：2018-03-20
申请号：US14579490
申请日：2014-12-22
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hanae Tagami , Hiroyuki Kato
CPC classification number: A61M37/0015 , A61K9/0014 , A61K9/0021 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B29C39/026 , B29K2001/08 , B29L2031/759
Abstract: A method for manufacturing a needle-shaped body, including supplying a first aqueous solution to an intaglio plate, supplying a second aqueous solution to the intaglio plate, drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed on the intaglio plate, and separating the dried body from the intaglio plate such that a needle-shaped body including a needle-shaped projection and a support base which supports the needle-shaped projection is obtained. The intaglio plate includes a recess corresponding to the needle-shaped projection, the first aqueous solution is supplied to fill at least a portion of the recess, the first aqueous solution and the second aqueous solution are immiscible, the first aqueous solution forms a projection side layer in the needle-shaped body, and the second aqueous solution forms a support base side layer on the projection side layer in the needle-shaped body.
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