公开(公告)号：US20190091315A1

公开(公告)日：2019-03-28

申请号：US16088682

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: A61K39/00 ,  A61P35/00

Abstract: The present application relates to a novel immunity-inducing agent for treatment and/or prevention of cancer. Specifically, the present application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from polypeptides derived from MCEMP1 and modified forms thereof, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo, and a method for inducing immunity, comprising administering the immunity-inducing agent to a subject.

公开(公告)号：US20230030982A1

公开(公告)日：2023-02-02

申请号：US17960354

申请日：2022-10-05

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: C07K16/30 ,  A61K45/00 ,  A61K38/00 ,  C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06

Abstract: An object of the present invention is to identify cancer antigen proteins specifically expressed on the surface of cancer cells and to provide a use of antibodies targeting such proteins as therapeutic and/or preventive agents for cancer. The present invention relates to, for example, a pharmaceutical composition for treatment and/or prevention of a cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with an MCEMP1 protein having an amino acid sequence shown in any one of the even numbered SEQ ID NOS: 2 to 8 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence, or with a fragment of the MCEMP1 protein comprising 7 or more consecutive amino acids.

公开(公告)号：US20190106505A1

公开(公告)日：2019-04-11

申请号：US16088502

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: An object of the present invention is to identify cancer antigen proteins specifically expressed on the surface of cancer cells and to provide a use of antibodies targeting such proteins as therapeutic and/or preventive agents for cancer. The present invention relates to, for example, a pharmaceutical composition for treatment and/or prevention of a cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with an MCEMP1 protein having an amino acid sequence shown in any one of the even numbered SEQ ID NOS: 2 to 8 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence, or with a fragment of the MCEMP1 protein comprising 7 or more consecutive amino acids.

公开(公告)号：US20190112370A1

公开(公告)日：2019-04-18

申请号：US16088727

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of a cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with an MRAP2 protein having the amino acid sequence shown in SEQ ID NO: 2, 4, 6, or 8 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence, or with a fragment of the MRAP2 protein comprising 7 or more consecutive amino acids.

公开(公告)号：US20190076492A1

公开(公告)日：2019-03-14

申请号：US16084100

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: A61K35/76 ,  A61K39/39 ,  A61P35/00 ,  C07K14/54 ,  C07K14/555 ,  C07K14/705 ,  C07K14/47

Abstract: The present invention relates to a novel immunity-inducing agent for treatment and/or prevention of cancer. Specifically, the present invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from polypeptides derived from MRAP2 and modified forms thereof, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo, and a method for inducing immunity, comprising administering the immunity-inducing agent to a subject.

公开(公告)号：US20180085453A1

公开(公告)日：2018-03-29

申请号：US15567496

申请日：2016-04-28

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Hyongi CHON ,  Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: A61K39/395 ,  C07K4/12

Abstract: An object of the present invention is to identify a cancer antigen protein specifically expressed on the surface of cancer cells and provide use of an antibody targeting the cancer antigen protein as a therapeutic and/or prophylactic agent for cancer. A pharmaceutical composition for treating and/or preventing cancer comprising an antibody or a fragment thereof having immunological reactivity with CSPG5 protein consisting of any one of amino acid sequences represented by SEQ ID NOs: 8, 4, 6, 10, and 12 and an amino acid sequence having an amino acid identity of 80% or more to the amino acid sequence, or a fragment thereof consisting of 7 or more consecutive amino acids, as an active ingredient.