公开(公告)号：US11186591B2

公开(公告)日：2021-11-30

申请号：US16818512

申请日：2020-03-13

申请人： TORQUR AG ,  UNIVERSITÄT BASEL

发明人： Vladimir Cmiljanovic ,  Paul Hebeisen ,  Florent Beaufils ,  Thomas Bohnacker ,  Denise Rageot ,  Alexander Sele ,  Matthias Wymann ,  Jean-Baptiste Langlois

IPC分类号： C07D413/14 ,  C07D498/08 ,  A61K31/53 ,  C07D401/14 ,  C07D405/14 ,  C07D401/04 ,  C07D403/04 ,  C07D239/48 ,  C07D491/048 ,  C07D491/056 ,  C07D491/20 ,  C07D519/00 ,  A61P35/00 ,  C07D417/14 ,  C07D491/107 ,  C07D491/18

摘要： The invention relates to novel phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR) and PI3K-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.