公开(公告)号：US20240282424A1

公开(公告)日：2024-08-22

申请号：US18654586

申请日：2024-05-03

申请人： Universität Basel

发明人： Gabor Szinnai ,  Gilbert Koch ,  Marc Pfister ,  Johannes Schropp ,  Britta Steffens ,  Freya Bachmann

IPC分类号： G16H20/10 ,  A61B5/024 ,  G06N3/02 ,  G16H50/50

CPC分类号： G16H20/10 ,  A61B5/02438 ,  G06N3/02 ,  G16H50/50

摘要： The present description relates to a method for automatically determining an optimal individual dosing regimen of at least one drug. The method includes providing a mathematical model adapted to model a progression of said disease and an effect of the at least one drug on the progression of the disease, the model comprising individual model parameters associated with the patient. The method includes utilizing an empirical Bayesian estimation to automatically and numerically estimate the individual model parameters of the mathematical model. The method includes automatically calculating an optimal individual dosing regimen for the mathematical model by solving an optimal control problem based on a desired progression of the disease, the estimated individual model parameters, and an initial guess for the dosing regimen. The method includes adjusting the optimal individual dosing regimen to optionally account for at least one clinical constraint to yield the optimal individual dosing regimen.

公开(公告)号：US20240060812A1

公开(公告)日：2024-02-22

申请号：US18260077

申请日：2021-12-16

申请人： Endress+Hauser SE+Co. KG ,  Universität Basel

发明人： Raphael Kuhnen ,  Mohammad Sadegh Ebrahimi ,  Johannes Kölbl

IPC分类号： G01F23/292

CPC分类号： G01F23/2922

摘要： A sensor device for determining and/or monitoring a process variable of a medium in a container includes: a crystal body having at least one defect; and a magnetic field device for generating a magnetic field, the magnetic field device arranged such that a magnetic field can be generated in the region of the crystal body and in the region of the medium located within the container, so that a change of the magnetic field in the region of the crystal body is amplified, wherein the crystal body and the magnetic field device are arranged from the outside on a wall of the container. A method for determining and/or monitoring a process variable of a medium in a container using the sensor device is also disclosed.

公开(公告)号：US20240059650A1

公开(公告)日：2024-02-22

申请号：US18256992

申请日：2021-12-13

申请人： DSM IP ASSETS B.V. ,  UNIVERSITÄT BASEL

发明人： Werner BONRATH ,  Thomas BUCHHOLZ ,  Thomas NETSCHER ,  Jan SCHUETZ ,  Christof SPARR

IPC分类号： C07C407/00

CPC分类号： C07C407/00 ,  C07C2601/16

摘要： The present invention relates to the photooxidation of 2,4,6-trimethyl-phenol to yield 4-hydroperoxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one using methylene blue as photosensitizer in a solvent mixture of water and alcohols using light of the high wavelength range of the visible spectrum. This process allows 5 obtaining 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one and 2,3,5-trimethyl-hydroquinone in high yields and selectivity from 2,4,6-trimethylphenol.

公开(公告)号：US11904051B2

公开(公告)日：2024-02-20

申请号：US16966626

申请日：2019-01-31

申请人： Universität Basel ,  Universität Freiburg

发明人： Bert Müller ,  Andreas Zumbühl ,  Thomas Pfohl ,  Dennis Müller ,  Frederik Neuhaus ,  Radu Tanasescu ,  Till Saxer ,  Marzia Buscema ,  Sofiya Matviykiv ,  Gabriela Gerganova

IPC分类号： A61K9/127 ,  A61K47/24 ,  A61K47/44

CPC分类号： A61K9/127 ,  A61K47/24 ,  A61K47/44

摘要： A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically relevant shear stress.

公开(公告)号：US20240016370A1

公开(公告)日：2024-01-18

申请号：US18251450

申请日：2021-11-05

申请人： UNIVERSITÄT BASEL

发明人： Lorin FASEL ,  Nicolas GERIG ,  Georg RAUTER

IPC分类号： A61B1/005 ,  A61B1/00 ,  A61B1/008 ,  A61B90/00

CPC分类号： A61B1/0052 ,  A61B1/00006 ,  A61B1/0057 ,  A61B1/008 ,  A61B90/06 ,  A61B2090/064

摘要： An endodevice is disclosed with tension control. The endodevice includes a back end unit with an endoscopic unit coupled thereto. The back end unit includes first and second sensor elements, wherein the first sensor element is arranged between a drive member and a first spring element and the second sensor element is arranged between another end of the first spring element and a first tendon coupler. Each of the first and second sensor elements are configured to generate a sensor signal wherein the first sensor element, the second sensor element and the drive member are connected to a control unit. The control unit is configured to obtain sensor signals from the first sensor element and the second sensor element and to compute a deflection of the first spring element on the basis of the sensor signals obtained from the first sensor element and the second sensor element.

公开(公告)号：US20230344201A1

公开(公告)日：2023-10-26

申请号：US18005605

申请日：2021-07-15

申请人： UNIVERSITÄT BASEL

发明人： Richard J. WARBURTON ,  Alisa JAVADI ,  Daniel NAJER ,  Natasha TOMM

IPC分类号： H01S5/34 ,  H01S5/10 ,  H01S5/04 ,  G02B21/06 ,  H01S5/183

CPC分类号： H01S5/3412 ,  H01S5/1042 ,  H01S5/041 ,  G02B21/06 ,  H01S5/18361

摘要： The present invention relates to a single photon source, comprising: a microcavity arranged between a concave first minor and a semiconductor heterostructure forming a planar second minor, wherein the microcavity supports an optical mode, a quantum dot embedded in the semiconductor heterostructure and facing the first minor, and a laser light source configured to provide laser light in the microcavity to excite the quantum dot to emit single photons exiting the microcavity.

公开(公告)号：US11702459B2

公开(公告)日：2023-07-18

申请号：US16563987

申请日：2019-09-09

申请人： UNIVERSITÄT BASEL

发明人： Gennaro De Libero ,  Marco Lepore ,  Lucia Mori

IPC分类号： C07K14/725 ,  C12N5/0783 ,  G01N1/30 ,  G01N33/569 ,  C12N5/09 ,  C12N15/85 ,  A61K35/17 ,  A61P35/00

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0636 ,  C12N5/0693 ,  C12N15/85 ,  G01N1/30 ,  G01N33/56966 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2502/1114 ,  C12N2502/30

摘要： The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells.
The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

公开(公告)号：US20230193320A1

公开(公告)日：2023-06-22

申请号：US17948313

申请日：2022-09-20

申请人： UNIVERSITÄT BASEL

发明人： Mara KORNETE ,  Lukas JEKER

IPC分类号： C12N15/90 ,  C12N15/10 ,  A61P35/00 ,  A61K35/17 ,  A61K35/28 ,  C12N5/0783 ,  C12N5/0789

CPC分类号： C12N15/902 ,  C12N15/102 ,  A61P35/00 ,  A61K35/17 ,  A61K35/28 ,  C12N5/0636 ,  C12N5/0647

摘要： The invention relates to a method to determine a homology directed repair (HDR) event within a eukaryotic cell, wherein the cell expresses a first isoform of a surface protein, which is different from a second isoform of said surface protein with regard to an amino acid marker. The method comprises the steps of inducing a DNA double strand break, providing a HDR template DNA construct comprising the amino acid marker corresponding to the second isoform of the surface protein and subsequently determining the expression of the first or second isoform of said surface protein on said cell, wherein expression of the second isoform indicates a successful HDR event. The invention also relates to a method for editing a genomic location of interest within a eukaryotic cell, and to a method of selectively depleting or enriching an edited cell in a composition of non-edited and edited cells.

公开(公告)号：US11617495B2

公开(公告)日：2023-04-04

申请号：US16624990

申请日：2018-06-25

申请人： UNIVERSITÄT BASEL

发明人： Manuela Eugster ,  Patrick Weber ,  Georg Rauter

IPC分类号： A61B18/24 ,  A61B34/30 ,  A61B1/00 ,  A61B34/20 ,  A61B18/00

摘要： A medical endodevice for an intervention inside a human or animal body includes an elongated liaising structure having a distal end arrangeable inside a body of the human or animal being and a proximal end arrangeable outside the body while the distal end is inside the body. The endodevice has an intervention tool arranged to manipulate a target tissue inside the human or animal body. The intervention tool is arranged at the distal end of the liaising structure. The endodevice further includes a positioning unit having a moving formation arranged to dislocate the intervention tool relative to the target tissue, and an anchoring formation arranged to fix the moving formation to a fixing tissue inside the human or animal body such that the target tissue is positioned in a workspace of the intervention tool.

公开(公告)号：US20220337963A1

公开(公告)日：2022-10-20

申请号：US17849272

申请日：2022-06-24

申请人： Massachusetts Eye and Ear Infirmary ,  Universität Basel

发明人： Hideko Heidi Nakajima ,  Christof Theodor Stieger ,  Darcy Lynn Frear ,  Hannes Maier

IPC分类号： H04R25/00 ,  A61N1/36

摘要： To account for the anatomical variability of the round window, and its surrounding bony structure, and ensure the safety of the delicate round window membrane (RWM) and structures in the cochlea closely adjacent to the RWM, the disclosure provides devices and methods that safely and effectively couple the motion of a variety of actuators to the RWM.