公开(公告)号：US3822348A

公开(公告)日：1974-07-02

申请号：US27267472

申请日：1972-07-17

申请人： TOYO JOZO KK

发明人： TAKE T ,  WATANABE S ,  HIGASHI T ,  ABE J ,  OTANI M

IPC分类号： A61K35/60 ,  A61K38/00 ,  C07K14/46 ,  A61K17/00

CPC分类号： C07K14/46 ,  A61K35/60 ,  A61K38/00

摘要： A HORMONE-LIKE SUBSTANCE OF POLYEPTIDE TYPE HAVING SERUM CALCIUM REDUCING PROPERTY IN MAMMALS, WHICH IS ISOLATED FROM AN EEL, GENUS ANGUILLA, BY EXTRACTING HEART, PARTICUALRLY PERICARDIAL MEMBRANE AND/OR A TISSURE COMPRISING VENA CAVA ATTACHED TO OESOPHAGUS NEAR THE HEART WITH AN EXTRACTION SOLVENT, I.E. WATER, DILUTE ORGANIC ACID, DILUTE MINERAL ACID OR A MIXTURE OF WATER, HYDROPHILLIC ORGANIC SOLVENT AND AT LEAST ONE OF THE DILUTE ACIDS, AND REMOVING CONTAMINATING PROTEINS FROM THE RESULTING EXTRACT OR FROM AN EXTRACT LIQUID OBTAINED BY REMOVING SOLID FROM SAID EXTRACT. THE SUBSTANCE IS USEFUL FOR TREATMENT OF VARIOUS METABOLIC OSTEOLOGICAL DISEASE, FOR EXPAMPLE, OSTEOPETROSIS AND GERONOTOLOGICAL DISEASES. THE EELS USED ARE PREFERABLY THOSE BRED IN SEA WATER OR AN AQUEOUS SODIUM CHLORIDE SOLUTION SIMILAR IN COMPOSITION THERETO.