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    IL-5 inhibiting 6-azauracil derivatives
    1.
    发明授权
    IL-5 inhibiting 6-azauracil derivatives 失效
    IL-5抑制6-氮尿嘧啶衍生物

    公开(公告)号：US06867207B2

    公开(公告)日：2005-03-15

    申请号：US09891888

    申请日：2001-06-26

    申请人： Jean Fernand Armand Lacrampe ,  Eddy Jean Edgard Freyne ,  Marc Gaston Venet ,  Gustaaf Maria Boeckx

    发明人： Jean Fernand Armand Lacrampe ,  Eddy Jean Edgard Freyne ,  Marc Gaston Venet ,  Gustaaf Maria Boeckx

    IPC分类号： A61P37/08 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D253/065 ,  A61K31/53 ,  A61K17/00

    CPC分类号： C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

    摘要： The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, p and q are 0, 1, 2, 3 or 4 and q is also 5; X is O, S, NR3 or a direct bond; R1 is hydrogen, hydroxy, halo, optionally substituted amino, optionally substituted C1-6alkyl, C1-6alkyloxy, C3-7cycloalkyl or aryl; R2 is aryl, Het1, C3-7cycloalkyl, optionally substituted C1-6alkyl; and if X is O, S or NR3, then R2 may also be a carbonyl or thiocarbonyl linked substituent; R3 is hydrogen or C1-4alkyl; R4 and R5 independently are optionally substituted C1-6alkyl, halo, hydroxy, mercapto, C1-6alkyloxy, C1-6akylthio, C1-6alkylcarbonyloxy, aryl, cyano, nitro, Het3, R6 or NR7R8; R6 is substituted sulfonyl or sulfinyl; R7 and R8 are hydrogen, optionally substituted C1-4alkyl, aryl, a carbonyl or thiocarbonyl linked substituent, C3-7cycloalkyl, Het3 and R6; R9 and R10 are each independently selected from hydrogen, optionally substituted C1-4alkyl, phenyl, a carbonyl or thiocarbonyl linked substituent, C3-7cycloalkyl, Het3 and R6; R11 is hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, C1-4alkyloxy, carboxyl, C1-4alkyloxycarbonyl, trihaloC1-4alkylsulfonyloxy, R6, NR7R8, C(═O)NR7R8, aryl, aryloxy, arylcarbonyl, C3-7cycloalkyl, C3-7cycloalkyloxy, phthalimide-2-yl, Het3 and C(═O)Het3; R12 and R13 are each independently selected from hydrogen, optionally substituted C1-4alkyl, phenyl, a carbonyl or thiocarbonyl linked substituent, C3-7cycloalkyl and R6; aryl is optionally substituted phenyl; Het1, Het2 and Het3 are optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.

    摘要翻译： 本发明涉及配制N-氧化物的化合物，其药学上可接受的加成盐及其立体化学异构形式，p和q分别为0,1,2,3或4，q也为5; X是O，S，NR 3或直接键; R 1是氢，羟基，卤素，任选取代的氨基，任选取代的C 1-6烷基，C 1-6烷氧基，C 3-7环烷基或芳基; R 2是芳基，Het 1，C 3-7环烷基，任选取代的C 1-6烷基; 并且如果X是O，S或NR 3，则R 2也可以是羰基或硫代羰基连接的取代基; R 3是氢或C 1-4烷基; R 4和R 5独立地是任选取代的C 1-6烷基，卤素，羟基，巯基，C 1-6烷氧基，C 1-6烷硫基，C 1-6烷基羰基氧基，芳基，氰基，硝基，Het 3， 或NR 7 R 8; R 6是取代的磺酰基或亚磺酰基; R 7和R 8是氢，任选取代的C 1-4烷基，芳基，羰基或硫代羰基连接的取代基，C 3-7环烷基，Het 3和R 6; R 9和R 10各自独立地选自氢，任选取代的C 1-4烷基，苯基，羰基或硫代羰基连接的取代基，C 3-7环烷基，Het 3和R 6; R 11是羟基，巯基，氰基，硝基，卤素，三卤代甲基，C 1-4烷氧基，羧基，C 1-4烷氧基羰基，三卤代C 1-4烷基磺酰氧基，R 6，NR 7 R 8，C（= O） NR 7 R 8，芳基，芳氧基，芳基羰基，C 3-7环烷基，C 3-7环烷氧基，邻苯二甲酰亚胺-2-基，Het 3和C（= O）Het 3; R 12和R 13各自独立地选自氢，任选取代的C 1-4烷基，苯基，羰基或硫代羰基连接的取代基，C 3-7环烷基和R 6; 芳基是任选取代的苯基; Het <1>，Het <

    Reproduction processes for cellular bodies
    4.
    发明授权
    Reproduction processes for cellular bodies 失效
    细胞体的生殖过程

    公开(公告)号：US3854470A

    公开(公告)日：1974-12-17

    申请号：US41860473

    申请日：1973-11-23

    申请人： AUGSPURGER L

    发明人： AUGSPURGER L

    IPC分类号： C12N15/09 ,  A01K67/02 ,  A01K67/027 ,  A61D7/00 ,  A61D19/00 ,  A61K35/54 ,  C12N5/06 ,  A61K17/00 ,  A61K17/06

    CPC分类号： A61D7/00 ,  A61D19/04 ,  A61K35/54

    摘要： Disclosed a process for making greater use of female gametes in herbivorous mannals. The techniques include methods of obtaining ova from donor, preparation of recipients, detection of oestrus, and transplant techniques. Also disclosed are methods of making greater desired use of ova of these mammals. Among those are techniques by sex determination, for freezing and thawing eggs, for tissue culture of eggs and for clonal production of like embroyos utilized for transplantation to achieve a greater number of clonal differentiated cellular bodies having like genetic characteristics.

    摘要翻译： 公开了一种在食草性甘露中更多地利用雌性配子的方法。 这些技术包括从供体获得ova的方法，接受者的准备，发情的检测和移植技术。 还公开了使这些哺乳动物更好地使用卵的方法。 其中包括通过性别测定技术，用于冻结和解冻卵，用于卵的组织培养和用于移植的类似栓塞的克隆产生以实现更多数目具有类似遗传特征的克隆分化的细胞体。

    Novel oral pharmaceutical dosage form
    5.
    发明授权
    Novel oral pharmaceutical dosage form 失效
    新型口服药物剂型

    公开(公告)号：US3828106A

    公开(公告)日：1974-08-06

    申请号：US21520872

    申请日：1972-01-03

    申请人： BIOLOG CONCEPTS INC

    发明人： RUDEL H

    IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K31/565 ,  A61K31/57 ,  A61K17/00

    CPC分类号： A61K31/57 ,  A61K9/145 ,  A61K9/2013 ,  A61K31/565

    摘要： A PHARMACEUTICAL PREPARATION SUITABLE FOR ORAL ADMINISTRATION COMPRISES AN ACTIVE THEREAPEUTIC INGREDIENT IS SILID SOLUTION WITH A STEROIDAL LIPID, TOGETHER WITH A PHARMACEUTICALLY ACCEPTABLE CARRIER FOR SAID MIXTURE. THE THEREPEUTIC INGREDIENT MAY BE, FOR EXAMPLE, A NATURAL STEROID HORMONE, AND THE LIPID MAY BE A STEROL. THE PREPARATION MAY BE PROVIDED IN UNIT DOSAGE FORMS SUCH AS TABLETS, LOZENGES, CAPSULES, AND THE LIKE.

    Hormone-like substance having serum calcium reducing property
    6.
    发明授权
    Hormone-like substance having serum calcium reducing property 失效
    具有血清钙减少性质的类胡萝卜素物质

    公开(公告)号：US3822348A

    公开(公告)日：1974-07-02

    申请号：US27267472

    申请日：1972-07-17

    申请人： TOYO JOZO KK

    发明人： TAKE T ,  WATANABE S ,  HIGASHI T ,  ABE J ,  OTANI M

    IPC分类号： A61K35/60 ,  A61K38/00 ,  C07K14/46 ,  A61K17/00

    CPC分类号： C07K14/46 ,  A61K35/60 ,  A61K38/00

    摘要： A HORMONE-LIKE SUBSTANCE OF POLYEPTIDE TYPE HAVING SERUM CALCIUM REDUCING PROPERTY IN MAMMALS, WHICH IS ISOLATED FROM AN EEL, GENUS ANGUILLA, BY EXTRACTING HEART, PARTICUALRLY PERICARDIAL MEMBRANE AND/OR A TISSURE COMPRISING VENA CAVA ATTACHED TO OESOPHAGUS NEAR THE HEART WITH AN EXTRACTION SOLVENT, I.E. WATER, DILUTE ORGANIC ACID, DILUTE MINERAL ACID OR A MIXTURE OF WATER, HYDROPHILLIC ORGANIC SOLVENT AND AT LEAST ONE OF THE DILUTE ACIDS, AND REMOVING CONTAMINATING PROTEINS FROM THE RESULTING EXTRACT OR FROM AN EXTRACT LIQUID OBTAINED BY REMOVING SOLID FROM SAID EXTRACT. THE SUBSTANCE IS USEFUL FOR TREATMENT OF VARIOUS METABOLIC OSTEOLOGICAL DISEASE, FOR EXPAMPLE, OSTEOPETROSIS AND GERONOTOLOGICAL DISEASES. THE EELS USED ARE PREFERABLY THOSE BRED IN SEA WATER OR AN AQUEOUS SODIUM CHLORIDE SOLUTION SIMILAR IN COMPOSITION THERETO.

    Composition of methionine with 2-dimethylaminoethanol
    8.
    发明授权
    Composition of methionine with 2-dimethylaminoethanol 失效
    甲磺酸与2-二甲基氨基乙醇的组成

    公开(公告)号：US3819480A

    公开(公告)日：1974-06-25

    申请号：US29079172

    申请日：1972-09-21

    申请人： HOCHSCHILD R

    发明人： HOCHSCHILD R

    IPC分类号： A61K31/195 ,  A61K17/00

    CPC分类号： A61K31/195 ,  A61K31/13

    摘要： A therapeutic composition of methionine with 2dimethylaminoethanol in aqueous media. A method of extending life span in animals and the survival time of cells, tissues and organs in vitro by treatment with a mixture of methionine and 2dimethylaminoethanol or materials which form 2-dimethylaminoethanol in aqueous media.

    摘要翻译： 含水介质中甲硫氨酸与2-二甲基氨基乙醇的治疗组合物。 通过用蛋氨酸和2-二甲基氨基乙醇的混合物或在水性介质中形成2-二甲基氨基 - 乙醇的物质进行体外延长动物的寿命和细胞，组织和器官的存活时间的方法。

    Method of using steroid acetonides as growth promoting agents
    10.
    发明授权
    Method of using steroid acetonides as growth promoting agents 失效
    使用甾体丙酮酸作为生长促进剂的方法

    公开(公告)号：US3772435A

    公开(公告)日：1973-11-13

    申请号：US3772435D

    申请日：1971-11-02

    申请人： AMERICAN CYANAMID CO

    发明人： WILBUR R

    IPC分类号： A23K1/165 ,  A61K17/00

    CPC分类号： A23K20/168

    摘要： ENCHANCEMENT OF THE GROWTH RATE OF FEMALE RUMINANT ANIMALS BY PARENTERALLY ADMINSTERING TO SAID ANIMALS, IN A SINGLE DOSE, A GROWTH-ENCHANCING AMOUNT OF A SELECTED DERIVATIVE OF CERTAIN HALOGENATED 16A, 17A-DIHYDROXYSTEROIDS OF THE PREGNANE SERIES.