专利检索 ap:("TRAMES BIO, INC.") AND inv:"Albena KANTARDZHIEVA" 第 1 页

1.

发明公开
ADENO-ASSOCIATED VIRUS CAPSIDS AND ENGINEERED LIGAND-GATED ION CHANNELS FOR TREATING FOCAL EPILEPSY AND NEUROPATHIC PAIN 审中-公开

公开(公告)号：US20240108760A1

公开(公告)日：2024-04-04

申请号：US18273867

申请日：2022-01-25

申请人： TRAMES BIO, INC.

发明人： Annahita KERAVALA , Edward YEH , Albena KANTARDZHIEVA

IPC分类号： A61K48/00 , A61K9/00 , A61P25/08 , C12N5/0793 , C12N15/86

CPC分类号： A61K48/0016 , A61K9/0019 , A61P25/08 , C12N5/0619 , C12N15/86 , C12N2750/14143

摘要： The present disclosure provides compositions and methods for treating neuropathic pain or focal epilepsy. Further provided are AAV capsid polypeptides and/or nucleic acids suitable for transducing neurons related to neuropathic pain or focal epilepsy. The disclosure relates to AAV vectors comprising specific capsid polypeptides that provides desirable transduction efficiency and/or tropism for neurons responsible for neuropathic pain or focal epilepsy management.