公开(公告)号：US20170215394A1

公开(公告)日：2017-08-03

申请号：US15329477

申请日：2014-07-31

申请人： TRANSGENIC INC. ,  NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY

发明人： Kenichi YAMAMURA ,  Takao IWAWAKI ,  Daisuke OIKAWA ,  Tomoo ISHIKAWA

IPC分类号： A01K67/027 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K67/027 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0368 ,  A61K49/0008 ,  C12N15/09

摘要： The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.

公开(公告)号：US20220340926A1

公开(公告)日：2022-10-27

申请号：US17614237

申请日：2019-05-27

申请人： TRANSGENIC INC.

发明人： Kenichi YAMAMURA ,  Zhenghua LI

IPC分类号： C12N15/85 ,  C12N15/11 ,  A01K67/027

摘要： Provided are a donor vector having an exon-humanized gene in which only exon nucleotide sequences of a mouse gene are replaced with human exon nucleotide sequences, an ES cell in which a mouse endogenous gene is replaced with the donor vector, and a mouse crated by using the ES cell.

公开(公告)号：US20180360006A1

公开(公告)日：2018-12-20

申请号：US15736899

申请日：2015-06-18

申请人： TRANSGENIC INC.

发明人： Kenichi YAMAMURA ,  Zhenghua LI

IPC分类号： A01K67/027 ,  C12N5/0735

摘要： The present invention provides embryonic stem cells obtained from an embryo of a mouse engineered to replace all or some of domains in the mouse MHC class I molecule H2-D with domains from the human MHC class I molecule HLA-A by culture in the presence of a GSK3 inhibitor and an MEK inhibitor, as well as a mouse which is created with the use of these embryonic stem cells.