公开(公告)号：US20230355524A1

公开(公告)日：2023-11-09

申请号：US18352615

申请日：2023-07-14

申请人： TRANSLATE BIO, INC.

发明人： Lianne BOEGLIN ,  Christopher GUENARD ,  Khang Anh TRAN ,  Anusha DIAS ,  Frank DEROSA

IPC分类号： A61K9/107 ,  C07K16/28 ,  A61K48/00 ,  A61K9/00

CPC分类号： A61K9/1075 ,  C07K16/2866 ,  A61K48/0033 ,  A61K9/007 ,  A61K2039/505

摘要： The present invention provides, among other things, method of treating an immune disease in a subject, the method comprising: administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody that binds to a protein target selected from IL-4, IL-5, IL-6, IL-9, IL-13, IL-25, or IL-33, IL-4R, IL-5R, IL-6R, IL-9R, IL-13R, IL-25R or IL-33R, and wherein the one or more mRNAs are encapsulated in a lipid nanoparticle (LNP). The present invention also provides, among other things, a composition comprising one or more mRNAs encoding a heavy chain and a light chain of an antibody that binds a protein target selected from IL-4, IL-5, IL-6, IL-9, IL-13, IL-25, or IL-33, IL-4R, IL-5R, IL-6R, IL-9R, IL-13R, IL-25R or IL-33R, and wherein the one or more mRNAs are encapsulated in a lipid nanoparticle (LNP).