公开(公告)号：US20240342269A1

公开(公告)日：2024-10-17

申请号：US17923497

申请日：2021-05-07

申请人： TRANSLATE BIO, INC.

发明人： Anusha DIAS ,  Khang Anh TRAN ,  Minnie ZACHARIA ,  Xiaobo GU ,  Lianne BOEGLIN ,  Joseph A. SKALESKI ,  Shrirang KARVE ,  Frank DEROSA ,  Tong-Ming FU ,  Kirill KALNIN ,  Sudha CHIVUKULA ,  Timothy PLITNIK ,  Danilo CASIMIRO ,  Jeffrey S. DUBINS

IPC分类号： A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005

CPC分类号： A61K39/215 ,  A61K9/5123 ,  A61P31/14 ,  C07K14/005 ,  A61K2039/53 ,  C12N2770/20022 ,  C12N2770/20034

摘要： The present invention relates to optimized nucleotide sequence encoding SARS-COV-2 antigens. These sequences are particularly suitable for use in vaccine compositions for the treatment or prevention of infections caused by a β-coronaviruses, including COVID-19 infections, in a human or animal subject in need of such treatment.

公开(公告)号：US20230355524A1

公开(公告)日：2023-11-09

申请号：US18352615

申请日：2023-07-14

申请人： TRANSLATE BIO, INC.

发明人： Lianne BOEGLIN ,  Christopher GUENARD ,  Khang Anh TRAN ,  Anusha DIAS ,  Frank DEROSA

IPC分类号： A61K9/107 ,  C07K16/28 ,  A61K48/00 ,  A61K9/00

CPC分类号： A61K9/1075 ,  C07K16/2866 ,  A61K48/0033 ,  A61K9/007 ,  A61K2039/505

摘要： The present invention provides, among other things, method of treating an immune disease in a subject, the method comprising: administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody that binds to a protein target selected from IL-4, IL-5, IL-6, IL-9, IL-13, IL-25, or IL-33, IL-4R, IL-5R, IL-6R, IL-9R, IL-13R, IL-25R or IL-33R, and wherein the one or more mRNAs are encapsulated in a lipid nanoparticle (LNP). The present invention also provides, among other things, a composition comprising one or more mRNAs encoding a heavy chain and a light chain of an antibody that binds a protein target selected from IL-4, IL-5, IL-6, IL-9, IL-13, IL-25, or IL-33, IL-4R, IL-5R, IL-6R, IL-9R, IL-13R, IL-25R or IL-33R, and wherein the one or more mRNAs are encapsulated in a lipid nanoparticle (LNP).

公开(公告)号：US20230190954A1

公开(公告)日：2023-06-22

申请号：US17923839

申请日：2021-05-07

申请人： TRANSLATE BIO, INC.

发明人： Caroline J. WOO ,  Anusha DIAS ,  Khang Anh TRAN ,  Lianne BOEGLIN ,  Nicholas K. CLARK ,  John ANDROSAVICH ,  Shraddha SHARMA ,  Gang SUN ,  Neha KAUSHAL ,  Shrirang KARVE

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K47/24 ,  A61K9/00 ,  A61K47/22 ,  A61K47/18

CPC分类号： A61K48/0008 ,  A61K9/0078 ,  A61K38/1709 ,  A61K47/22 ,  A61K47/24 ,  A61K47/183 ,  A61K48/0066 ,  A61K48/0075 ,  A61K48/0083 ,  A61P11/00

摘要： The present invention provides, among other things, methods and compositions for treating primary ciliary dyskinesia (PCD) based on mRNA therapy. The compositions used in treatment of PCD comprise an mRNA comprising a dynein axonemal intermediate chain 1 (DNAI1) coding sequence and are administered at an effective dose and an administration interval such that at least one symptom or feature of PCD is reduced in intensity, severity, or frequency or has a delayed onset. mRNAs with optimized DNAI1 coding sequences are provided that can be administered without the need for modifying the nucleotides of the mRNA to achieve sustained in vivo function.

公开(公告)号：US20230181619A1

公开(公告)日：2023-06-15

申请号：US17923470

申请日：2021-05-07

申请人： TRANSLATE BIO, INC.

发明人： Anusha DIAS ,  Khang Anh TRAN ,  Lianne BOEGLIN ,  Frank DEROSA ,  John ANDROSAVICH ,  Shraddha SHARMA ,  Gang SUN ,  Neha KAUSHAL ,  Shrirang KARVE

IPC分类号： A61K31/7105 ,  A61K9/127 ,  A61K31/47 ,  A61K9/00 ,  A61P11/00

CPC分类号： A61K31/7105 ,  A61K9/1271 ,  A61K31/47 ,  A61K9/0078 ,  A61P11/00

摘要： The present invention provides, among other things, improved methods and pharmaceutical compositions for treating cystic fibrosis based on codon optimized mRNA encoding a wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein.