公开(公告)号：US20210236611A1

公开(公告)日：2021-08-05

申请号：US17249362

申请日：2021-02-26

申请人： TREOS BIO LIMITED

发明人： Levente MOLNÁR ,  Eniko R. TOKE ,  Julianna LISZIEWICZ ,  József TÓTH ,  Orsolya LORINCZ ,  Zsolt CSISZOVSZKI ,  Eszter SOMOGYI ,  Katalin PÁNTYA ,  Mónika MEGYESI ,  Péter PÁLES

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61P37/04

摘要： The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.