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公开(公告)号:US20220233660A1
公开(公告)日:2022-07-28
申请号:US17250722
申请日:2019-09-03
申请人: TREOS BIO LIMITED
发明人: Julianna LISZEWICZ , Levente MOLNAR , Eniko TOKE , József TOTH , Orsolya LORINCZ , Zsolt CSISZOVSZKI , Eszter SOMOGYI , Katalin PANTYA , Péter PÁLES , István MIKLÓS , Mónika MEGYESI
IPC分类号: A61K39/00 , C12Q1/6881 , G16B20/20 , G16B20/30 , G01N33/574 , A61P35/00
摘要: The disclosure relates to a method for determining the risk that a human subject will develop a cancer, the method comprising quantifying the HLA triplets (HEAT) of the subject that are capable of binding to T cell epitopes in the amino acid sequence of tumor associated antigens. The disclosure also relates to methods of treating subjects who are determined to have an elevated risk of developing cancer.
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公开(公告)号:US20230102031A1
公开(公告)日:2023-03-30
申请号:US17250725
申请日:2019-09-03
申请人: TREOS BIO LIMITED
发明人: Julianna LISZEWICZ , Levente MOLNAR , Eniko TOKE , József TOTH , Orsolya LORINCZ , Zsolt CSISZOVSZKI , Eszter SOMOGYI , Katalin PANTYA , Mónika MEGYESI
摘要: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.
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公开(公告)号:US20210236611A1
公开(公告)日:2021-08-05
申请号:US17249362
申请日:2021-02-26
申请人: TREOS BIO LIMITED
发明人: Levente MOLNÁR , Eniko R. TOKE , Julianna LISZIEWICZ , József TÓTH , Orsolya LORINCZ , Zsolt CSISZOVSZKI , Eszter SOMOGYI , Katalin PÁNTYA , Mónika MEGYESI , Péter PÁLES
摘要: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.
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