公开(公告)号：US10646614B2

公开(公告)日：2020-05-12

申请号：US15975132

申请日：2018-05-09

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Mark W. Grinstaff ,  Cynthia Ghobril ,  Michel Christophe Wathier ,  Marlena Dagmara Konieczynska

IPC分类号： A61L26/00 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L24/00

摘要： The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).

公开(公告)号：US09993577B2

公开(公告)日：2018-06-12

申请号：US14901858

申请日：2014-06-30

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Mark W. Grinstaff ,  Cynthia Ghobril ,  Michel Christophe Wathier ,  Marlena Dagmara Konieczynska

IPC分类号： C12N5/02 ,  A61L26/00 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L24/00

CPC分类号： A61L26/008 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L26/0028 ,  A61L26/0066 ,  A61L26/009 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

摘要： The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).

公开(公告)号：US20160287745A1

公开(公告)日：2016-10-06

申请号：US14901858

申请日：2014-06-30

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Mark W. Grinstaff ,  Cynthia Ghobril ,  Michel Christophe Wathier ,  Marlena Dagmara Konieczynska

IPC分类号： A61L26/00

CPC分类号： A61L26/008 ,  A61L15/44 ,  A61L15/60 ,  A61L15/64 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L26/0028 ,  A61L26/0066 ,  A61L26/009 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

摘要： The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).

摘要翻译： 本文提供的发明涉及可溶解的水凝胶组合物和使用方法，例如但不限于伤口管理。 因此，本文还提供涉及可溶性水凝胶组合物的伤口处理方法。 在一些实施方案中，可溶解的水凝胶组合物包含粘合剂硫酯水凝胶，其可以促进可溶性氢组合物粘附到表面（例如伤口）上，并且在加入硫醇盐化合物以释放可溶解水凝胶组合物后可以可控地溶解 从表面（例如，伤口）。