公开(公告)号：US11584792B2

公开(公告)日：2023-02-21

申请号：US17501050

申请日：2021-10-14

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Nelson Ruiz-Opazo ,  Victoria Herrera

IPC分类号： C07K16/24 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61P31/14

摘要： Described herein are methods of treating COVID19 from a coronavirus infection, methods of treating a subject having a coronavirus infection, methods of improving a survival rate of a subject having a coronavirus infection, methods of determining prognosis of a subject having a coronavirus infection, methods of preventing or treating organ-dysfunction or multi-organ dysfunction or failure associated with a coronavirus infection, methods of combinational therapy for a subject having a coronavirus infection, methods of reducing microthrombi formation or low flow organ-ischemia associated with a coronavirus infection by administering a DEspR inhibitor.

公开(公告)号：US10953107B2

公开(公告)日：2021-03-23

申请号：US16441208

申请日：2019-06-14

申请人： Trustees of Boston University

发明人： Mark W. Grinstaff ,  Christopher Gromisch ,  Victoria Herrera ,  Nelson Ruiz-Opazo

IPC分类号： A61K47/42 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00 ,  A61P11/00

摘要： Described herein are methods and compositions related to compositions comprising combinations of V/K-type and V/E-type docking peptides and uses thereof, e.g., to deliver therapeutic agents to treat certain conditions such as cancer, infection, or trauma.