公开(公告)号：US08367373B2

公开(公告)日：2013-02-05

申请号：US12514730

申请日：2007-11-15

申请人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

发明人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

IPC分类号： C12P21/02

CPC分类号： C07K14/465 ,  C12N15/85 ,  C12N2830/008 ,  C12N2830/90

摘要： An oviduct specific expression promoter and a recombinant expression vector including the same. A promoter of an AGR2 gene is expressed specifically in the chicken oviduct, and a recombinant expression vector includes the promoter and a desired gene for encoding a desired protein. The oviduct specific promoter and the recombinant expression vector including the promoter can induce the expression of a protein specifically in the oviduct, i.e., an organ that secrets proteins so as to accumulate with a large amount in the egg. Accordingly, the oviduct specific promoter and the recombinant expression vector of the present invention can be advantageously used to produce transformed chickens, which can massively yield useful elements of high added value, produce functional eggs, and improve the economic traits of the poultry.

摘要翻译： 输卵管特异性表达启动子和包含其的重组表达载体。 AGR2基因的启动子在鸡输卵管中特异性表达，重组表达载体包含启动子和用于编码所需蛋白质的所需基因。 输卵管特异性启动子和包含启动子的重组表达载体可以在输卵管中特异性诱导蛋白质的表达，即分泌蛋白质以在卵中大量积聚的器官。 因此，本发明的输卵管特异性启动子和重组表达载体可以有利地用于产生转化的鸡，其可以大量产生高附加值的有用元件，产生功能性蛋，并且改善家禽的经济性状。

公开(公告)号：US20100167343A1

公开(公告)日：2010-07-01

申请号：US12514730

申请日：2007-11-15

申请人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

发明人： Tae Yoon Kim ,  Sang Hoon Kim ,  Ik Soo Jeon ,  Sung Jun Byun ,  Dong Heon Shin ,  Nam Soo Kim

IPC分类号： C12P21/00 ,  C07H21/04 ,  C12N15/74 ,  C12N5/071

CPC分类号： C07K14/465 ,  C12N15/85 ,  C12N2830/008 ,  C12N2830/90

摘要： An oviduct specific expression promoter and a recombinant expression vector including the same. A promoter of an AGR2 gene is expressed specifically in the chicken oviduct, and a recombinant expression vector includes the promoter and a desired gene for encoding a desired protein. The oviduct specific promoter and the recombinant expression vector including the promoter can induce the expression of a protein specifically in the oviduct, i.e., an organ that secrets proteins so as to accumulate with a large amount in the egg. Accordingly, the oviduct specific promoter and the recombinant expression vector of the present invention can be advantageously used to produce transformed chickens, which can massively yield useful elements of high added value, produce functional eggs, and improve the economic traits of the poultry.

摘要翻译： 输卵管特异性表达启动子和包含其的重组表达载体。 AGR2基因的启动子在鸡输卵管中特异性表达，重组表达载体包含启动子和用于编码所需蛋白质的所需基因。 输卵管特异性启动子和包含启动子的重组表达载体可以在输卵管中特异性诱导蛋白质的表达，即分泌蛋白质以在卵中大量积聚的器官。 因此，本发明的输卵管特异性启动子和重组表达载体可以有利地用于产生转化的鸡，其可以大量产生高附加值的有用元件，产生功能性蛋，并且改善家禽的经济性状。