公开(公告)号：US5756123A

公开(公告)日：1998-05-26

申请号：US797622

申请日：1997-02-07

申请人： Taizo Yamamoto ,  Seinosuke Matsuura ,  Kazukiyo Akai

发明人： Taizo Yamamoto ,  Seinosuke Matsuura ,  Kazukiyo Akai

IPC分类号： A61K9/48

CPC分类号： A61K9/4816

摘要： A capsule shell comprising 79.6-98.7% by weight of a hydroxypropylmethyl cellulose, 0.03-0.5% by weight of carrageenan, and 0.14-3.19% by weight of a potassium ion and/or a calcium is prepared by drying an solution comprising 18-28% by weight of hydroxypropylmethyl cellulose whose 2% aqueous solution has a viscosity of 2.4-5.4 centistokes at 20.degree. C. as a base, 0.01-0.09% by weight of carrageenan as a gelling agent, and 0.05-0.6% by weight of a potassium ion and/or calcium ion as a co-gelling agent. The capsule shell exhibits disintegrating ability equivalent to gelatin shells without degrading that ability even under special conditions containing much calcium ions.

摘要翻译： 制备包含79.6-98.7重量％的羟丙基甲基纤维素，0.03-0.5重量％角叉菜胶和0.14-3.19重量％钾离子和/或钙的胶囊壳，其通过将包含18-28 羟丙基甲基纤维素的重量百分数为2％的水溶液在20℃粘度为2.4-5.4厘沲为基础，0.01-0.09重量％的作为胶凝剂的角叉菜胶，0.05-0.6重量％ 钾离子和/或钙离子作为共胶凝剂。 胶囊壳体即使在含有大量钙离子的特殊条件下也具有相当于明胶壳的崩解能力，而不会降低该能力。