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公开(公告)号：US06413463B1
公开(公告)日：2002-07-02
申请号：US09582560
申请日：2000-06-29
IPC分类号： A61K948
CPC分类号： A61K9/4816
摘要： A method of manufacturing hard capsules is characterized by comprising the steps of dispersing a water-soluble cellulose derivative in hot water and cooling the dispersion to effect dissolution of the water-soluble cellulose derivative in the water, adding and dissolving a gelling agent in the water-soluble cellulose derivative solution to give a capsule-preparing solution, dipping a capsule-forming pin into the capsule-preparing solution at a predetermined temperature, then drawing out the pin and inducing gelation of the capsule-preparing solution adhering to the pin.
摘要翻译： 制造硬胶囊的方法的特征在于包括将水溶性纤维素衍生物分散在热水中并冷却分散体以使水溶性纤维素衍生物溶解在水中的步骤，在水中加入和溶解胶凝剂 可溶性纤维素衍生物溶液，得到胶囊制剂溶液，将胶囊形成针在预定温度下浸入胶囊制备溶液中，然后拉出针并引起粘附在针上的胶囊制备溶液的凝胶化。
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公开(公告)号：US5756123A
公开(公告)日：1998-05-26
申请号：US797622
申请日：1997-02-07
IPC分类号： A61K9/48
CPC分类号： A61K9/4816
摘要： A capsule shell comprising 79.6-98.7% by weight of a hydroxypropylmethyl cellulose, 0.03-0.5% by weight of carrageenan, and 0.14-3.19% by weight of a potassium ion and/or a calcium is prepared by drying an solution comprising 18-28% by weight of hydroxypropylmethyl cellulose whose 2% aqueous solution has a viscosity of 2.4-5.4 centistokes at 20.degree. C. as a base, 0.01-0.09% by weight of carrageenan as a gelling agent, and 0.05-0.6% by weight of a potassium ion and/or calcium ion as a co-gelling agent. The capsule shell exhibits disintegrating ability equivalent to gelatin shells without degrading that ability even under special conditions containing much calcium ions.
摘要翻译： 制备包含79.6-98.7重量％的羟丙基甲基纤维素，0.03-0.5重量％角叉菜胶和0.14-3.19重量％钾离子和/或钙的胶囊壳，其通过将包含18-28 羟丙基甲基纤维素的重量百分数为2％的水溶液在20℃粘度为2.4-5.4厘沲为基础，0.01-0.09重量％的作为胶凝剂的角叉菜胶，0.05-0.6重量％ 钾离子和/或钙离子作为共胶凝剂。 胶囊壳体即使在含有大量钙离子的特殊条件下也具有相当于明胶壳的崩解能力，而不会降低该能力。
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公开(公告)号：US5431917A
公开(公告)日：1995-07-11
申请号：US114351
申请日：1993-09-01
申请人： Taizo Yamamoto , Kenji Abe , Seinosuke Matsuura
发明人： Taizo Yamamoto , Kenji Abe , Seinosuke Matsuura
IPC分类号： A61K9/48
CPC分类号： A61K9/4816 , Y10S514/962
摘要： A hard capsule for pharmaceutical drugs comprises a water-soluble cellulose derivative as a capsule base, a gelatinizing agent and an auxiliary for gelation. The hard capsule is prepared by preparing an aqueous solution of a capsule base containing a water-soluble cellulose derivative, a gelatinizing agent and an auxiliary for gelation, immersing a capsule molding pin in the aqueous solution of the capsule base, subsequently drawing out the molding pin from the aqueous solution of the capsule base, subjecting the aqueous solution of the capsule base attached to the outer surface of the molding pin to gelate at room temperature, and forming a capsule film on the outer surface of the molding pin.
摘要翻译： 用于药物的硬胶囊包含作为胶囊基的水溶性纤维素衍生物，胶凝剂和凝胶助剂。 通过制备含有水溶性纤维素衍生物，凝胶化剂和凝胶助剂的胶囊基底水溶液，将胶囊成型销浸渍在胶囊基材的水溶液中，随后拉出成型制备硬胶囊 从胶囊基体的水溶液引出，使附着在成形销的外表面的胶囊基体的水溶液在室温下凝胶化，在成形销的外表面形成胶囊膜。
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公开(公告)号：US5264223A
公开(公告)日：1993-11-23
申请号：US957892
申请日：1992-10-08
申请人： Taizo Yamamoto , Kenji Abe , Seinosuke Matsuura
发明人： Taizo Yamamoto , Kenji Abe , Seinosuke Matsuura
CPC分类号： A61K9/4816
摘要： A hard capsule for pharmaceutical drugs comprises a water-soluble cellulose derivative as a capsule base, a gelatinizing agent and an auxiliary for gelation. The hard capsule is prepared by preparing an aqueous solution of a capsule base containing a water-soluble cellulose derivative, a gelatinizing agent and an auxiliary for gelation, immersing a capsule molding pin in the aqueous solution of the capsule base, subsequently drawing out the molding pin from the aqueous solution of the capsule base, subjecting the aqueous solution of the capsule base attached to the outer surface of the molding pin to gelate at room temperature, and forming a capsule film on the outer surface of the molding pin.
摘要翻译： 用于药物的硬胶囊包含作为胶囊基的水溶性纤维素衍生物，胶凝剂和凝胶助剂。 通过制备含有水溶性纤维素衍生物，凝胶化剂和凝胶助剂的胶囊基底水溶液，将胶囊成型销浸渍在胶囊基材的水溶液中，随后拉出成型制备硬胶囊 从胶囊基体的水溶液引出，使附着在成形销的外表面的胶囊基体的水溶液在室温下凝胶化，在成形销的外表面形成胶囊膜。
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5.发明授权Hard capsule formed of cellulose ether film with a specific content of methoxyl and hydroxypropoxyl groups 有权硬胶囊由纤维素醚膜形成，具有特定含量的甲氧基和羟丙氧基公开(公告)号：US06649180B1
公开(公告)日：2003-11-18
申请号：US09549205
申请日：2000-04-13
申请人： Seinosuke Matsuura , Masaru Tanjoh
发明人： Seinosuke Matsuura , Masaru Tanjoh
IPC分类号： B29D2200
CPC分类号： C08J5/18 , A61K9/4816 , C08J2301/28 , C08L1/28 , Y10T428/1307 , Y10T428/31971 , C08L2666/02
摘要： A cellulose ether film is formed of a composition comprising a cellulose ether as a base in which some of the hydrogen atoms of cellulosic hydroxyl groups are replaced by alkyl groups and/or hydroxyalkyl groups, a gelling agent, and a gelling aid. The total content of alkoxyl and hydroxyalkoxyl groups in the cellulose ether is limited to 23-37.6% by weight, which is effective for preventing the gelling aid from precipitating out and maintaining a favorable outer appearance during long-term storage.
摘要翻译： 纤维素醚膜由包含纤维素醚作为碱的组合物形成，其中纤维素羟基的一些氢原子被烷基和/或羟烷基取代，胶凝剂和胶凝助剂。 纤维素醚中的烷氧基和羟基烷氧基的总含量限于23-37.6重量％，这对于防止胶凝助剂在长期储存期间沉淀并保持良好的外观是有效的。
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公开(公告)号：US5419916A
公开(公告)日：1995-05-30
申请号：US95417
申请日：1993-07-22
CPC分类号： A61K9/4816 , Y10S514/962
摘要： There are disclosed herein a gelatin coating composition which comprises succinated gelatin as the main component and polyethylene glycol, and a hard gelatin capsule formed from said gelatin coating composition. The hard gelatin capsule has sufficient mechanical strength for filling operation. Moreover, it does not become insoluble due to reaction with a special drug having an aldehyde group filled therein. Therefore, it can be used for various drugs, especially macrolide antibiotics for which conventional hard gelatin capsules are inadequate.
摘要翻译： 本文公开了包含琥珀酸化明胶作为主要成分和聚乙二醇的明胶包衣组合物和由所述明胶包衣组合物形成的硬明胶胶囊。 硬明胶胶囊具有足够的机械强度用于填充操作。 此外，由于与其中填充有醛基的特殊药物反应，它不会变得不溶。 因此，它可用于各种药物，特别是常规硬明胶胶囊不足的大环内酯类抗生素。
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