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1.发明申请公开(公告)号：US20120245050A1
公开(公告)日：2012-09-27
申请号：US13498267
申请日：2010-10-25
申请人： Takachika Hiroi , Kimihiro Okubo
发明人： Takachika Hiroi , Kimihiro Okubo
IPC分类号： C40B30/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： [Problem] To provide a biomarker for predicting the therapeutic efficacy of allergen immunotherapy.[Means for solving the problem] A method for detecting the efficacy of allergen immunotherapy, the method comprising the steps of: detecting a copy number variation of at least one gene selected from the gene group, AGXT2L2, AZGP1, CAV3, CEP72, CUL4A, CXCR7, C12orf60, C16orf48, C19orf34, DNAJB8, FTH1, GEMIN4, GIGYF2, GJC3, HTT, ITCH, MARK2, METT10D, NAV3, NOB1, PAFAH2, PLEKHG4B, PPFIA1, SCARNA11, SDF2L1, SMPD3, SNORA44, SRP14, ST6GALNAC1, SULF2, TMED6, TYRP1, WFDC13, ZNFX1, NCAM2, PCDH17, CHODL, BTG3, DIAPH3, GBA3, IFRD1, KCNT2, THOC7, TMEM168, BST1, C7orf53, CD38, DCUN1D1, FGFBP1, FOXP2, GLRB, GTF2B, HSP90AB2P, MCCC1, MDFIC, ODF2L, PDGFC, SEP15, SH3GLB1, TDRD3, YEATS2, CCDC127, C14orf180, SIVA1, TNFRSF14, AHNAK2, C14orf79, LOC25845, PLD4, GPR132, LOC389257, BRF1 and ADSSL1, from a specimen to be examined collected from the subject; and correlating the obtained result from detecting the copy number variation with effectiveness of the allergen immunotherapy.
摘要翻译： [问题]提供用于预测变应原免疫治疗的治疗功效的生物标志物。 [解决问题的手段]一种检测变应原免疫治疗效果的方法，所述方法包括以下步骤：检测选自基因组AGXT2L2，AZGP1，CAV3，CEP72，CUL4A中的至少一种基因的拷贝数变异， CXCR7，C12orf60，C16orf48，C19orf34，DNAJB8，FTH1，GEMIN4，GIGYF2，GJC3，HTT，ITCH，MARK2，METT10D，NAV3，NOB1，PAFAH2，PLEKHG4B，PPFIA1，SCARNA11，SDF2L1，SMPD3，SNORA44，SRP14，ST6GALNAC1，SULF2， TMED6，TYRP1，WFDC13，ZNFX1，NCAM2，PCDH17，CHODL，BTG3，DIAPH3，GBA3，IFRD1，KCNT2，THOC7，TMEM168，BST1，C7orf53，CD38，DCUN1D1，FGFBP1，FOXP2，GLRB，GTF2B，HSP90AB2P，MCCC1，MDFIC， 从受试者收集的待检样本的ODF2L，PDGFC，SEP15，SH3GLB1，TDRD3，YEATS2，CCDC127，C14orf180，SIVA1，TNFRSF14，AHNAK2，C14orf79，LOC25845，PLD4，GPR132，LOC389257，BRF1和ADSSL1; 并将获得的结果与检测拷贝数变异与变应原免疫治疗的有效性相关联。
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公开(公告)号：US08029729B2
公开(公告)日：2011-10-04
申请号：US12088568
申请日：2005-09-28
申请人： Huaipeng Tang , Akihiro Seta , Toshihiro Anai , Toshikatsu Ueda , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
发明人： Huaipeng Tang , Akihiro Seta , Toshihiro Anai , Toshikatsu Ueda , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
IPC分类号： F24F7/06
CPC分类号： A61G10/00
摘要： An object of the present invention is to solve the problems in conventional art antigen exposure chambers, and specifically, to provide an antigen exposure chamber system capable of simultaneously exposing a large number of test objects in a chamber to a uniform antigen (pollen, mite or house dust, etc.) in all seasons. In order to achieve the above object, in an antigen exposure chamber system according to the present invention, an outdoor air is supplied via an outdoor air diffuser 2 provided in a ceiling surface of an exposure chamber 1 into the exposure chamber from the ceiling surface of the exposure chamber in a horizontal direction, a fan unit 15, including a supply port and a suction port, is provided in each of the four corners of the exposure chamber to provide a circulating flow of air flowing with circulation in the horizontal direction in the exposure chamber, an air exhaust port 4 is provided at a floor surface of the exposure chamber to exhaust an air from the floor surface of the exposure chamber, an antigen is supplied from an antigen supply device to the outdoor air diffuser provided on the ceiling surface so that the antigen is mixed with the outdoor air, and a uniform concentration antigen exposure is enabled by the circulating flow of air.
摘要翻译： 本发明的目的是解决现有技术的抗原暴露室中的问题，具体而言，提供一种抗原暴露室系统，其能够将室内的大量被检物体同时暴露于均匀的抗原（花粉，螨或 房屋灰尘等）。 为了实现上述目的，在本发明的抗原暴露室系统中，室外空气经由设置在曝光室1的顶面的室外空气扩散器2从天花板的顶面供给到曝光室 曝光室在水平方向上，风扇单元15包括供给口和吸入口，设置在曝光室的四个角中的每一个中，以提供沿着水平方向流动的空气的循环流动 曝光室，在曝光室的地板表面设有排气口4，以从曝光室的地板表面排出空气，将抗原从抗原供应装置供应到设置在天花板表面上的室外空气扩散器 使得抗原与室外空气混合，并且通过空气的循环流使得均匀的浓度抗原暴露。
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公开(公告)号：US07819987B2
公开(公告)日：2010-10-26
申请号：US12088516
申请日：2005-09-28
申请人： Toshio Fujita , Huaipeng Tang , Akihiro Seta , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
发明人： Toshio Fujita , Huaipeng Tang , Akihiro Seta , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
IPC分类号： B08B3/04
摘要： An antigen exposure chamber for quickly performing cleaning and drying with high quality is provided. The antigen exposure chamber of the present invention includes: a cleaning water supply device for supplying cleaning water for cleaning the antigen exposure chamber; cleaning nozzles for jetting the cleaning water supplied from the cleaning water supply device into the antigen exposure chamber and ducts of fan units to clean the antigen exposure chamber and the ducts; a floor surface of the antigen exposure chamber; and an exhaust device provided below the floor surface to exhaust air from the floor surface of the antigen exposure chamber and collect and drain the cleaning water during cleaning.
摘要翻译： 提供用于快速进行高质量清洗和干燥的抗原暴露室。 本发明的抗原暴露室包括：清洗用水供给装置，其用于供给用于清洗抗原暴露室的清洗水; 用于将从清洁水供应装置供应的清洁水喷射到抗原暴露室和风扇单元的管道中以清洁抗原暴露室和管道的清洁喷嘴; 抗原暴露室的地板表面; 以及设置在地板表面下方的排气装置，以从抗原暴露室的地板表面排出空气，并在清洁期间收集和排出清洁水。
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公开(公告)号：US20090145466A1
公开(公告)日：2009-06-11
申请号：US12088516
申请日：2005-09-28
申请人： Toshio Fujita , Huaipeng Tang , Akihiro Seta , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
发明人： Toshio Fujita , Huaipeng Tang , Akihiro Seta , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
IPC分类号： B08B3/02
摘要： An antigen exposure chamber for quickly performing cleaning and drying with high quality is provided. The antigen exposure chamber of the present invention includes: a cleaning water supply device for supplying cleaning water for cleaning the antigen exposure chamber; cleaning nozzles 23 and 24 for jetting the cleaning water supplied from the cleaning water supply device, into the antigen exposure chamber 1 and ducts 17 of fan units to clean the antigen exposure chamber 1 and the ducts 17; a floor surface 15 of the antigen exposure chamber; and an exhaust device provided below the floor surface to exhaust air from the floor surface of the antigen exposure chamber and collect and drain the cleaning water during cleaning. Further, the cleaning water supply device includes a water purifying device 19 for purifying tap water; a pure water tank 20 for storing the purified water; and a pure water supply pump 21 for pumping the pure water from the pure water tank into the cleaning nozzles. The exhaust device includes an air exhaust port 4 for exhausting air from the antigen exposure chamber; drain pans 14 for receiving and collecting the cleaning water flowing down from the antigen exposure chamber; a drain tank 27 for storing the cleaning water collected by the drain pans; a drain pump 28 for draining the cleaning water stored in the drain tank into a drain pipe; and a drying exhaust-air fan 29 for exhausting the air from the antigen exposure chamber through the drain tank to accelerate drying in the antigen exposure chamber after the cleaning water is drained.
摘要翻译： 提供用于快速进行高质量清洗和干燥的抗原暴露室。 本发明的抗原暴露室包括：清洗用水供给装置，其用于供给用于清洗抗原暴露室的清洗水; 用于将从清洗水供应装置供应的清洗水喷射到抗原暴露室1和风扇单元的管道17中以清洁抗原暴露室1和管道17的清洁喷嘴23和24; 抗原暴露室的地板表面15; 以及设置在地板表面下方的排气装置，以从抗原暴露室的地板表面排出空气，并在清洁期间收集和排出清洁水。 另外，清洗水供给装置具备净化自来水的净水装置19， 用于储存净化水的纯水罐20; 以及纯水供给泵21，用于将来自纯水箱的纯水泵送到清洗喷嘴中。 排气装置包括用于从抗原暴露室排出空气的排气口4; 排水盘14，用于接收和收集从抗原暴露室向下流动的清洁水; 排水槽27，用于储存由排水盘收集的清洗水; 用于将储存在排水槽中的清洗水排入排水管的排水泵28; 以及干燥废气风扇29，其用于通过排水槽排出来自抗原暴露室的空气，以在清洁水排出之后加速在抗原暴露室中的干燥。
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公开(公告)号：US08262988B2
公开(公告)日：2012-09-11
申请号：US12088520
申请日：2005-09-28
摘要： An antigen supply device 1 according to the present invention is mainly configured by a cylindrical member 3 extending in the vertical direction. An air suction port 5 for sucking the air in the antigen exposure chamber is provided at a lower end of the cylindrical member. An axial fan 6 that generates a flow of the air flowing upward in an axial direction of the cylindrical member is attached above the air suction port of the cylindrical member. Moreover, a supply port 4 through which high-concentration antigens are jetted from a dust feeder on the outside of the antigen exposure chamber is provided above the axial fan of the cylindrical member. The antigen supply device 1 is disposed near the outdoor air diffuser of the antigen exposure chamber, and configured to blow out high-concentration antigens, which are supplied from the dust feeder on the outside of the antigen exposure chamber, to the outdoor air diffuser 2 from an upper end of the cylindrical member after mixing the antigens with the air in the antigen exposure chamber sucked from the air suction port and diluting the antigens, and moreover mix the antigens with the outdoor air from the outdoor air diffuser to fill the antigen exposure chamber A with the mixture of the antigens and the outdoor air.
摘要翻译： 根据本发明的抗原供应装置1主要由沿垂直方向延伸的圆柱形构件3构成。 用于吸入抗原暴露室中的空气的吸气口5设置在圆筒形构件的下端。 在筒状部件的空气吸入口的上方，安装有沿筒状部件的轴向向上流动的空气流的轴流风扇6。 此外，在筒状部件的轴流风扇的上方设置有从抗原暴露室外侧的送粉器喷出高浓度抗原的供给口4。 抗原供给装置1配置在抗原暴露室的室外空气扩散器的附近，构成为将从抗原暴露室外侧的送粉装置供给的高浓度抗原吹送到室外空气扩散器2 将抗原与从空气吸入口吸入的抗原暴露室中的空气混合并稀释抗原之后，从圆柱形构件的上端开始，并将抗原与来自室外空气扩散器的室外空气混合以填充抗原暴露 室A与抗原和室外空气的混合物。
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公开(公告)号：US20090257919A1
公开(公告)日：2009-10-15
申请号：US12088568
申请日：2005-09-28
申请人： Huaipeng Tang , Akihiro Seta , Toshihiro Anai , Toshikatsu Ueda , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
发明人： Huaipeng Tang , Akihiro Seta , Toshihiro Anai , Toshikatsu Ueda , Minoru Okuda , Kazuhiro Hashigucci , Kimihiro Okubo
CPC分类号： A61G10/00
摘要： An object of the present invention is to solve the problems in conventional art antigen exposure chambers, and specifically, to provide an antigen exposure chamber system capable of simultaneously exposing a large number of test objects in a chamber to a uniform antigen (pollen, mite or house dust, etc.) in all seasons. In order to achieve the above object, in an antigen exposure chamber system according to the present invention, an outdoor air is supplied via an outdoor air diffuser 2 provided in a ceiling surface of an exposure chamber 1 into the exposure chamber from the ceiling surface of the exposure chamber in a horizontal direction, a fan unit 15, including a supply port and a suction port, is provided in each of the four corners of the exposure chamber to provide a circulating flow of air flowing with circulation in the horizontal direction in the exposure chamber, an air exhaust port 4 is provided at a floor surface of the exposure chamber to exhaust an air from the floor surface of the exposure chamber, an antigen is supplied from an antigen supply device to the outdoor air diffuser provided on the ceiling surface so that the antigen is mixed with the outdoor air, and a uniform concentration antigen exposure is enabled by the circulating flow of air.
摘要翻译： 本发明的目的是解决现有技术的抗原暴露室中的问题，具体而言，提供一种抗原暴露室系统，其能够将室内的大量被检物体同时暴露于均匀的抗原（花粉，螨或 房屋灰尘等）。 为了实现上述目的，在本发明的抗原暴露室系统中，室外空气经由设置在曝光室1的顶面的室外空气扩散器2从天花板的顶面供给到曝光室 曝光室在水平方向上，风扇单元15包括供给口和吸入口，设置在曝光室的四个角中的每一个中，以提供沿着水平方向流动的空气的循环流动 曝光室，在曝光室的地板表面设有排气口4，以从曝光室的地板表面排出空气，将抗原从抗原供应装置供应到设置在天花板表面上的室外空气扩散器 使得抗原与室外空气混合，并且通过空气的循环流使得均匀的浓度抗原暴露。
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公开(公告)号：US20090155146A1
公开(公告)日：2009-06-18
申请号：US12088520
申请日：2005-09-28
IPC分类号： B01J7/00
摘要： An antigen supply device 1 according to the present invention is mainly configured by a cylindrical member 3 extending in the vertical direction. An air suction port 5 for sucking the air in the antigen exposure chamber is provided at a lower end of the cylindrical member. An axial fan 6 that generates a flow of the air flowing upward in an axial direction of the cylindrical member is attached above the air suction port of the cylindrical member. Moreover, a supply port 4 through which high-concentration antigens are jetted from a dust feeder on the outside of the antigen exposure chamber is provided above the axial fan of the cylindrical member. The antigen supply device 1 is disposed near the outdoor air diffuser of the antigen exposure chamber, and configured to blow out high-concentration antigens, which are supplied from the dust feeder on the outside of the antigen exposure chamber, to the outdoor air diffuser 2 from an upper end of the cylindrical member after mixing the antigens with the air in the antigen exposure chamber sucked from the air suction port and diluting the antigens, and moreover mix the antigens with the outdoor air from the outdoor air diffuser to fill the antigen exposure chamber A with the mixture of the antigens and the outdoor air.
摘要翻译： 根据本发明的抗原供应装置1主要由沿垂直方向延伸的圆柱形构件3构成。 用于吸入抗原暴露室中的空气的吸气口5设置在圆筒形构件的下端。 在筒状部件的空气吸入口的上方，安装有沿筒状部件的轴向向上流动的空气流的轴流风扇6。 此外，在筒状部件的轴流风扇的上方设置有从抗原暴露室外侧的送粉器喷出高浓度抗原的供给口4。 抗原供给装置1配置在抗原暴露室的室外空气扩散器的附近，构成为将从抗原暴露室外侧的送粉装置供给的高浓度抗原吹送到室外空气扩散器2 将抗原与从空气吸入口吸入的抗原暴露室中的空气混合并稀释抗原之后，从圆柱形构件的上端开始，并将抗原与来自室外空气扩散器的室外空气混合以填充抗原暴露 室A与抗原和室外空气的混合物。
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