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公开(公告)号:US06511975B1
公开(公告)日:2003-01-28
申请号:US09616092
申请日:2000-07-13
IPC分类号: C07D41306
CPC分类号: C07D413/06
摘要: A compound of the formula (I) wherein R1 and R2 is a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group. A is CH2, CO or SO2. B is a single bond, alkylene or alkenylene. D is O or S. E is alkylene or alkenylene. wherein G is a substituted or unsubstituted cycloalkene ring, or a substituted cycloalkane ring. Ar is a substituted or unsubstituted aryl ring, or a substituted or unsubstituted heteroaryl ring. R3 is alkyl. n is 1-3. The invention includes a pharmacologically acceptable salt, ester or other derivative of a compound of the formula (I). The invention also provides pharmaceutical compositions and methods of treating specified diseases utilizing a compound of formula (I).
摘要翻译: 式(I)的化合物,其中R 1和R 2是取代或未取代的芳基,或取代或未取代的杂芳基。 A是CH 2,CO或SO 2。 B是单键,亚烷基或亚烯基。 D是O或S.E是亚烷基或亚烯基,其中G是取代或未取代的环烯烃环或取代的环烷烃环。 Ar是取代或未取代的芳基环,或取代或未取代的杂芳基环。 R3是烷基。 n为1-3。 本发明包括式(I)化合物的药学上可接受的盐,酯或其它衍生物。 本发明还提供了利用式(I)化合物治疗特定疾病的药物组合物和方法。