公开(公告)号：US20060194836A1

公开(公告)日：2006-08-31

申请号：US10548283

申请日：2004-03-05

申请人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimosa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

发明人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimosa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

IPC分类号： A61K31/4709 ,  A61K31/444 ,  C07D401/14

CPC分类号： C07D401/12 ,  C07D213/32 ,  C07D401/14

摘要： A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R1 and R2, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.

摘要翻译： 本发明的目的是提供一种新颖的具有4-吡啶基烷硫基作为取代基的五元或六元杂环衍生物或其盐，其可用作药物。 由以下通式[I]表示的化合物或其盐可用作涉及血管生成或增加血管通透性的疾病的治疗剂。 在该式中，环“A”是可以与环烷烃环稠合的苯环或芳族五元或六元杂环，“B”是亚烷基，R 1和R 2 相同或不同的是H，OH，取代或未取代的烷氧基等，X和Y相同或不同，为选自H，卤素，OH，取代或未取代的 烷氧基等，p为0,1或2，q为0或1。