公开(公告)号：US20100291545A1

公开(公告)日：2010-11-18

申请号：US12670383

申请日：2008-07-25

申请人： Takaji Wakita ,  Tetsuro Suzuki ,  Kenichi Morikawa ,  Noriaki Omi ,  Noriko Nakamura ,  Daisuke Akazawa

发明人： Takaji Wakita ,  Tetsuro Suzuki ,  Kenichi Morikawa ,  Noriaki Omi ,  Noriko Nakamura ,  Daisuke Akazawa

IPC分类号： C12Q1/70 ,  C07K16/10

CPC分类号： C07K16/109 ,  C07K14/005 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C12N2770/24222 ,  G01N2333/186

摘要： The objection of the invention is to provide an antibody that inhibits infection with hepatitis C virus (HCV). To this end, this invention provides an antibody that recognizes the hepatitis C virus (HCV) particle obtained from the hepatitis C virus (HCV) genome comprising the following (i) and (ii) ligated to each other as an antigen and has an inhibitory activity on infection with hepatitis C virus (HCV): (i) (a) the 5′-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the JFH-1 strain of the hepatitis C virus (HCV) or (b) the 5′-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the J6CF strain the hepatitis C virus (HCV); and (ii) the NS2 protein-encoding sequence, the NS3 protein-encoding sequence, the NS4A protein-encoding sequence, the NS4B protein-encoding sequence, the NS5A protein-encoding sequence, the NS5B protein-encoding sequence, and the 3′-untranslated region of the JFH-1 strain.

摘要翻译： 本发明的反对是提供抑制丙型肝炎病毒（HCV）感染的抗体。 为此，本发明提供一种抗体，其识别从丙型肝炎病毒（HCV）基因组获得的丙型肝炎病毒（HCV）颗粒，其包含以下（i）和（ii）作为抗原彼此连接并具有抑制性 丙型肝炎病毒（HCV）感染活动：（i）（a）5'非翻译区，核心蛋白编码序列，编码E1蛋白的序列，E2蛋白编码序列和p7蛋白 - 丙型肝炎病毒（HCV）的JFH-1株的编码序列或（b）5'-非翻译区，核心蛋白编码序列，E1蛋白编码序列，E2蛋白编码序列和 J6CF株丙型肝炎病毒（HCV）的p7蛋白编码序列; 和（ii）NS2蛋白编码序列，编码NS3蛋白的序列，NS4A蛋白编码序列，NS4B蛋白编码序列，NS5A蛋白编码序列，NS5B蛋白编码序列和3' JFH-1株的非翻译区。