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公开(公告)号：US10076570B2
公开(公告)日：2018-09-18
申请号：US13423193
申请日：2012-03-17
IPC分类号： A61K39/00 , A61K39/29 , C07K14/005 , A61K39/12
CPC分类号： A61K39/292 , A61K39/12 , A61K2039/53 , A61K2039/545 , C07K14/005 , C12N2710/10343 , C12N2710/24143 , C12N2730/10134 , C12N2770/24222
摘要： The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections.
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公开(公告)号：US20180169216A1
公开(公告)日：2018-06-21
申请号：US15888718
申请日：2018-02-05
申请人： Merial Inc.
IPC分类号： A61K39/135 , A61K39/385 , C07K14/005 , C07K14/32 , C12N7/00 , A61K39/00
CPC分类号： A61K39/135 , A61K39/385 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/6075 , C07K14/005 , C07K14/32 , C07K2319/40 , C07K2319/735 , C12N7/00 , C12N2770/24222 , C12N2770/32122 , C12N2770/32134 , C12N2770/32171
摘要： The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.
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公开(公告)号：US20170333550A1
公开(公告)日：2017-11-23
申请号：US15461978
申请日：2017-03-17
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/6031 , C12N7/00 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/24034 , C12N2710/24043 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234
摘要： The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed.
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公开(公告)号：US20170328905A1
公开(公告)日：2017-11-16
申请号：US15662784
申请日：2017-07-28
申请人： BIO-RAD INNOVATIONS
IPC分类号： G01N33/569 , C07K14/005
CPC分类号： G01N33/56983 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2469/10 , G01N2469/20
摘要： The invention relates to a method of in-vitro detection of an infection with a hepatitis C virus (HCV) in a biological sample, comprising the simultaneous detection of the HCV capsid protein and of an antibody directed against said capsid protein, said method using, for capturing the anti-capsid antibodies, a peptide comprising an antigenic fragment derived from the truncated HCV capsid. The invention also relates to the peptide for capturing the anti-capsid antibodies and the kits comprising it.
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公开(公告)号：US20170327803A1
公开(公告)日：2017-11-16
申请号：US15662173
申请日：2017-07-27
申请人： Abbott Laboratories
发明人： A. Scott Muerhoff , Christopher Marohnic , Larry Birkenmeyer , John Prostko , M. Felicia Bogdan , Robin Gutierrez
IPC分类号： C12N9/14 , G01N33/576 , C07K14/005
CPC分类号： C12N9/14 , C07K14/005 , C07K2319/20 , C07K2319/21 , C12N2770/24222 , C12N2800/22 , G01N33/5767 , G01N2469/20
摘要： The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies.
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公开(公告)号：US09751931B2
公开(公告)日：2017-09-05
申请号：US14437593
申请日：2012-10-26
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Federal Budgetary Research Institution State Research Center of Virology and Biotechnology “Vector”
IPC分类号： C07K16/10 , A61K39/29 , A61K45/06 , C07K14/005 , C12N7/00 , G01N33/576 , C12Q1/04 , A61K39/00
CPC分类号： C07K16/109 , A61K39/29 , A61K45/06 , A61K2039/5256 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2770/24222 , C12N2770/24234 , C12Q1/04 , G01N33/5767
摘要： Novel epitope regions on hepatitis C virus E1E2 glycoprotein that induce a neutralizing antibody response in vivo are identified. Cross-neutralizing monoclonal antibodies that bind specifically to the epitopes are disclosed.
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公开(公告)号：US09732121B2
公开(公告)日：2017-08-15
申请号：US14493153
申请日：2014-09-22
发明人： Steven Foung , Zhen-Yong Keck , Thomas R. Fuerst
IPC分类号： A61K39/29 , C07K14/005 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/55572 , A61K2039/57 , C12N7/00 , C12N2770/24222 , C12N2770/24234
摘要： Compositions and methods are provided relating to HCV E2 protein and modifications thereto which enhance the immunogenicity of the protein for vaccine development with respect to the generation of a neutralizing immune response.
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公开(公告)号：US20170215393A1
公开(公告)日：2017-08-03
申请号：US15514806
申请日：2015-10-01
发明人： Kevin Young , Lakshmi Krishnan
IPC分类号： A01K67/027 , C12N15/86 , C12N7/00 , C12N5/09
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/0331 , A01K2267/0337 , A01K2267/0393 , A61K39/12 , A61K2039/523 , A61K2039/5256 , C12N5/0693 , C12N7/00 , C12N15/85 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2840/206 , C12Q1/707
摘要： Modified non-human mammalian hepatoma cell lines that express hepatitis C virus (HCV) antigens and which are capable of generating tumours in a syngeneic animal model are provided. The cell lines are generated by genomic integration of an expression construct that comprises one or more HCV antigen-encoding sequences under the control of a constitutive promoter. The expression construct further comprises a selectable marker and a reporter gene under the control of the same promoter. The cell lines are useful for testing prophylactic and therapeutic vaccines against HCV either in vitro or in vivo.
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公开(公告)号：US09719994B2
公开(公告)日：2017-08-01
申请号：US14366368
申请日：2012-12-19
申请人： BIO-RAD INNOVATIONS
IPC分类号： G01N33/53 , G01N33/569 , C07K14/005
CPC分类号： G01N33/56983 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2469/10 , G01N2469/20
摘要： The invention relates to a method of in-vitro detection of an infection with a hepatitis C virus (HCV) in a biological sample, comprising the simultaneous detection of the HCV capsid protein and of an antibody directed against said capsid protein, said method using, for capturing the anti-capsid antibodies, a peptide comprising an antigenic fragment derived from the truncated HCV capsid. The invention also relates to the peptide for capturing the anti-capsid antibodies and the kits comprising it.
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公开(公告)号：US20170143819A1
公开(公告)日：2017-05-25
申请号：US15353727
申请日：2016-11-16
申请人： MERIAL INC.
IPC分类号： A61K39/135 , C07K14/005 , C12N7/00 , A61K39/385
CPC分类号： A61K39/135 , A61K39/385 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/6075 , C07K14/005 , C07K14/32 , C07K2319/40 , C07K2319/735 , C12N7/00 , C12N2770/24222 , C12N2770/32122 , C12N2770/32134 , C12N2770/32171
摘要： The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.
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