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公开(公告)号：US07378555B2
公开(公告)日：2008-05-27
申请号：US11517621
申请日：2006-09-08
IPC分类号： C07C209/36
CPC分类号： C07D213/64 , C07C205/22 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07D491/04 , C07D491/14 , Y02P20/55
摘要： The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
摘要翻译： 本发明是为了有效地制备对应于喜树碱（CPT）骨架的AB-环部分的2'-氨基-5'-羟基苯丙酮和对应于CDE-环部分的三环酮，以便通过全合成提供高效的CPT ，其为盐酸伊立替康和各种喜树碱衍生物的起始原料，并提供稳定的CPT及其衍生物。
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公开(公告)号：US20070010674A1
公开(公告)日：2007-01-11
申请号：US11517621
申请日：2006-09-08
IPC分类号： C07D471/14
CPC分类号： C07D213/64 , C07C205/22 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07D491/04 , C07D491/14 , Y02P20/55
摘要： The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
摘要翻译： 本发明是为了有效地制备对应于喜树碱（CPT）骨架的AB-环部分的2'-氨基-5'-羟基苯丙酮和对应于CDE-环部分的三环酮，以便通过全合成提供有效的CPT ，其为盐酸伊立替康和各种喜树碱衍生物的起始原料，并提供稳定的CPT及其衍生物。
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公开(公告)号：US07126000B2
公开(公告)日：2006-10-24
申请号：US10467987
申请日：2002-02-21
IPC分类号： C07D491/052
CPC分类号： C07D213/64 , C07C205/22 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07D491/04 , C07D491/14 , Y02P20/55
摘要： The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
摘要翻译： 本发明是为了有效地制备对应于喜树碱（CPT）骨架的AB-环部分的2'-氨基-5'-羟基苯丙酮和对应于CDE-环部分的三环酮，以便通过全合成提供有效的CPT ，其为盐酸伊立替康和各种喜树碱衍生物的起始原料，并提供稳定的CPT及其衍生物。
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公开(公告)号：US07897772B2
公开(公告)日：2011-03-01
申请号：US11576356
申请日：2005-09-29
IPC分类号： C07D401/02
CPC分类号： C07D491/22
摘要： The present invention is directed to an irinotecan acid addition salt which is formed through addition of an acid selected from the group consisting of sulfuric acid, nitric acid, phosphoric acid, methanesulfonic acid, citric acid, maleic acid, and succinic acid to irinotecan, to a method for producing the salt, and to a pharmaceutical composition containing the salt. The addition salt requires no heating process during drug preparation and provides an aqueous drug product in which the salt is stably dissolved.
摘要翻译： 本发明涉及通过向伊立替康中加入选自硫酸，硝酸，磷酸，甲磺酸，柠檬酸，马来酸和琥珀酸的酸形成的伊立替康酸加成盐， 盐的制造方法和含有该盐的药物组合物。 加成盐在药物制备过程中不需要加热过程，并提供其中盐稳定溶解的水性药物产品。
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公开(公告)号：US20070299099A1
公开(公告)日：2007-12-27
申请号：US11576356
申请日：2005-09-29
IPC分类号： A61K31/437 , A61P35/00 , C07D491/22
CPC分类号： C07D491/22
摘要： The present invention is directed to an irinotecan acid addition salt which is formed through addition of an acid selected from the group consisting of sulfuric acid, nitric acid phosphoric acid, methanesulfonic acid, citric acid maleic acid and succinic acid to Irinotecan, to a method for producing the salt, and to a pharmaceutical composition containing the salt. The addition salt requires no heating process during drug preparation and provides an aqueous drug product in which the salt is stably dissolved.
摘要翻译： 本发明涉及通过向伊立替康中加入选自硫酸，硝酸磷酸，甲磺酸，柠檬酸马来酸和琥珀酸的酸形成的伊立替康酸加成盐， 产生盐，以及含有该盐的药物组合物。 加成盐在药物制备过程中不需要加热过程，并提供其中盐稳定溶解的水性药物产品。
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