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公开(公告)号：US06803472B2
公开(公告)日：2004-10-12
申请号：US10296925
申请日：2002-11-29
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07D20730
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
摘要翻译： 一种合成方法，其包括在甲硅烷基化剂存在下使含NH基的化合物与硫氰酸酯，氰胺，亚硝酸酯或酯反应以合成相应的含氮加成或取代产物。 该方法不仅可以直接有效地合成含氮化合物，包括异硫脲，胍，脒和酰胺，而且还具有广泛的应用范围，适用于大规模合成。
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公开(公告)号：US06960689B2
公开(公告)日：2005-11-01
申请号：US10954605
申请日：2004-10-01
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07C231/02 , C07C233/07 , C07C257/14 , C07C257/18 , C07C277/02 , C07C279/18 , C07C335/32 , C07C257/10 , C07C335/30
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
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公开(公告)号：US20050049421A1
公开(公告)日：2005-03-03
申请号：US10957603
申请日：2004-10-05
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07C231/02 , C07C233/07 , C07C257/14 , C07C257/18 , C07C277/02 , C07C279/18 , C07C335/32
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
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公开(公告)号：US20050043569A1
公开(公告)日：2005-02-24
申请号：US10956040
申请日：2004-10-04
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07C231/02 , C07C233/07 , C07C257/14 , C07C257/18 , C07C277/02 , C07C279/18 , C07C335/32 , C07C257/02
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
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公开(公告)号：US07087783B2
公开(公告)日：2006-08-08
申请号：US10956040
申请日：2004-10-04
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07C231/02 , C07C277/02 , C07C257/10 , C07C335/30 , C07C335/32
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
摘要翻译： 一种合成方法，其包括在甲硅烷基化剂存在下使含NH基的化合物与硫氰酸酯，氰胺，腈或酯反应以合成相应的含氮添加或取代产物。 该方法不仅可以直接有效地合成含氮化合物，包括异硫脲，胍，脒和酰胺，而且还具有广泛的应用范围，适用于大规模合成。
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公开(公告)号：US06946576B2
公开(公告)日：2005-09-20
申请号：US10957603
申请日：2004-10-05
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07C231/02 , C07C233/07 , C07C257/14 , C07C257/18 , C07C277/02 , C07C279/18 , C07C335/32 , C07C257/10 , C07C335/30
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
摘要翻译： 一种合成方法，其包括在甲硅烷基化剂存在下使含NH基的化合物与硫氰酸酯，氰胺，亚硝酸酯或酯反应以合成相应的含氮加成或取代产物。 该方法不仅可以直接有效地合成含氮化合物，包括异硫脲，胍，脒和酰胺，而且还具有广泛的应用范围，适用于大规模合成。
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公开(公告)号：US20050075513A1
公开(公告)日：2005-04-07
申请号：US10954605
申请日：2004-10-01
申请人： Takashi Emura , Tsuyoshi Haneishi
发明人： Takashi Emura , Tsuyoshi Haneishi
IPC分类号： C07C231/02 , C07C233/07 , C07C257/14 , C07C257/18 , C07C277/02 , C07C279/18 , C07C335/32
CPC分类号： C07C335/32 , C07C231/02 , C07C257/14 , C07C257/18 , C07C277/02 , C07C233/07 , C07C279/18
摘要： A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
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公开(公告)号：US07935688B2
公开(公告)日：2011-05-03
申请号：US11916955
申请日：2006-06-09
IPC分类号： A01N31/00 , A61K31/655 , A61K31/192 , A61K31/341 , A61K31/382 , A61K31/426 , A61K31/4418 , A61K31/4433 , A61K31/4436 , A61K31/50 , A61K31/505 , A61P3/02 , C07C598/48
CPC分类号： C07D307/42 , C07C51/00 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/64 , C07C59/68 , C07C59/90 , C07C65/19 , C07C229/36 , C07C259/06 , C07C259/10 , C07C271/22 , C07C309/65 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/55 , C07D237/08 , C07D239/26 , C07D277/30 , C07D307/54 , C07D307/68 , C07D309/10 , C07D333/16 , C07D335/02 , C07D405/10 , C07D409/10 , C07F5/025
摘要： The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound, and the like. The compound or a pharmaceutically acceptable salt thereof, the pharmaceutical composition containing such a compound, or the like is useful as a medicine or the like for therapy of benign prostatic hyperplasia, cancer, osteoporosis, psoriasis, secondary hyperparathyroidism, chronic glomerulonephritis, lupus nephritis and/or diabetic nephropathy and the like.
摘要翻译： 本发明提供由以下通式（I）表示的化合物或其药学上可接受的盐，含有这种化合物的药物组合物等。 该化合物或其药学上可接受的盐，含有这种化合物的药物组合物等可用作治疗良性前列腺增生，癌症，骨质疏松症，牛皮癣，继发性甲状旁腺功能亢进，慢性肾小球性肾炎，狼疮性肾炎的药物等。 /或糖尿病性肾病等。
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公开(公告)号：US08212059B2
公开(公告)日：2012-07-03
申请号：US12095734
申请日：2006-11-30
申请人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
发明人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
IPC分类号： C07C401/00 , C07J21/00
CPC分类号： C07C401/00 , C07J41/00 , C07J71/00
摘要： There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is characterized by irradiating a compound represented by the formula: with UV to ring-open the compound, and then isomerizing the resulting compound; an intermediate useful for carrying out the process; and a process for producing the intermediate.
摘要翻译： 提供了一种制备[{（5Z，7E） - （1S，3R，20S）-1,3-二羟基-9,10-断孕甾-5,7,10（19），16-四烯-20 - 基}氧基] -N-（2,2,3,3,3-五氟丙基）乙酰胺，该方法的特征在于用UV照射化合物以紫外线打开化合物，然后异构化所得 复合; 用于执行该过程的中间件; 和中间体的制造方法。
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公开(公告)号：US20100261917A1
公开(公告)日：2010-10-14
申请号：US12095734
申请日：2006-11-30
申请人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
发明人： Akira Kawase , Yasuharu Kato , Kazutomo Kinoshita , Yasushi Kitoh , Takuma Ikeda , Tsuyoshi Haneishi , Noriaki Maruyama , Mio Kobayashi
CPC分类号： C07C401/00 , C07J41/00 , C07J71/00
摘要： There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is characterized by irradiating a compound represented by the formula: with UV to ring-open the compound, and then isomerizing the resulting compound; an intermediate useful for carrying out the process; and a process for producing the intermediate.
摘要翻译： 提供了一种制备[{（5Z，7E） - （1S，3R，20S）-1,3-二羟基-9,10-断孕甾-5,7,10（19），16-四烯-20 - 基}氧基] -N-（2,2,3,3,3-五氟丙基）乙酰胺，该方法的特征在于用UV照射化合物以紫外线打开化合物，然后异构化所得 复合; 用于执行该过程的中间件; 和中间体的制造方法。
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