公开(公告)号：US5591757A

公开(公告)日：1997-01-07

申请号：US418262

申请日：1995-04-06

申请人： Takashi Fujikura ,  Noriki Ito ,  Yuzo Matsumoto ,  Masaharu Asano ,  Toichi Takenaka

发明人： Takashi Fujikura ,  Noriki Ito ,  Yuzo Matsumoto ,  Masaharu Asano ,  Toichi Takenaka

IPC分类号： A61K31/4427 ,  A61K31/455 ,  A61P3/00 ,  A61P3/14 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  C07D211/90 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D211/90

摘要： Pharmaceutical composition of certain dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The pharmaceutical compositions contains either 4-(2-hydroxy-3-phenoxy-propylamino)-butyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or 6-(2-hydroxy-3-phenoxypropylamino) hexyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or their pharmaceutically acceptable salts.

摘要翻译： 提供某些二氢吡啶化合物及其盐的药物组合物，其表现出Ca 2+拮抗剂和肾上腺素能β受体阻断活性，因此可用于治疗缺血性心脏病和高血压。 药物组合物含有4-（2-羟基-3-苯氧基 - 丙基氨基） - 丁基甲基2,6-二甲基-4-（间硝基苯基）-1,4-二氢吡啶-3,5-二羧酸酯或6-（ 2-羟基-3-苯氧基丙基氨基）己基甲基2,6-二甲基-4-（间硝基苯基）-1,4-二氢吡啶-3,5-二羧酸酯或其药学上可接受的盐。

公开(公告)号：US4727082A

公开(公告)日：1988-02-23

申请号：US908350

申请日：1986-09-17

申请人： Takashi Fujikura ,  Noriki Ito ,  Yuzo Matsumoto ,  Yasuo Isomura ,  Masaharu Asano ,  Toichi Takenaka

发明人： Takashi Fujikura ,  Noriki Ito ,  Yuzo Matsumoto ,  Yasuo Isomura ,  Masaharu Asano ,  Toichi Takenaka

IPC分类号： C07D211/82 ,  A61K31/44 ,  A61K31/455 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  A61P25/28 ,  C07D211/90 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07C317/00 ,  C07C323/00 ,  C07D211/90

摘要： A dihydropyridine compound of the following general formula (I) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represents a C.sub.1 to C.sub.10 alkyl group, a lower alkyl group which is interrupted by oxygen atom(s), or a lower alkyl group substituted by C.sub.3 to C.sub.6 alicyclic group(s); R.sup.3 and R.sup.4, which are the same or different, each represents a lower alkyl group; R.sup.5 and R.sup.6, which are the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group, or a lower alkylsulfinyl group; R.sup.7 and R.sup.8, which are the same or different, each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkoxy group, or a lower alkanoylamino group, or R.sup.7 may combine with R.sup.8 to form a naphthyl group together with the adjacent phenyl group; A represents a single bond, a vinylene group (--CH.dbd.CH--), or a ethynylene group (--C.dbd.C--); B represents a single bond or --CH.sub. 2 O--; and m and n, which are the same or different, each represents 0 or an integer of 1 to 5.The compounds are useful for the treatment of various cardiovascular disorders, since they possess both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities.

摘要翻译： 下列通式（I）的二氢吡啶化合物或其盐：其中R 1和R 2相同或不同，各自表示C1至C10烷基，低级烷基 其被氧原子或被C3-C6脂环族基团取代的低级烷基取代; R 3和R 4相同或不同，各自表示低级烷基; R 5和R 6相同或不同，分别表示氢原子，硝基，卤素原子，低级烷基，低级烷氧基，低级烷硫基，低级烷基磺酰基或低级烷基亚磺酰基 ; R 7和R 8相同或不同，各自表示氢原子，卤素原子，氰基，低级烷氧基或低级烷酰氨基，或者可以与R 8结合形成萘基， 相邻苯基; A表示单键，亚乙烯基（-CH = CH-）或亚乙炔基（-C = C-）; B表示单键或-CH 2 O-; 和m和n相同或不同，各自表示0或1至5的整数。该化合物可用于治疗各种心血管疾病，因为它们具有Ca 2+拮抗剂和肾上腺素能β受体阻断活性。

公开(公告)号：US5110820A

公开(公告)日：1992-05-05

申请号：US611340

申请日：1990-11-13

申请人： Takashi Fujikura ,  Noriki Ito ,  Yuzo Matsumoto ,  Masaharu Asano ,  Toichi Takenaka

发明人： Takashi Fujikura ,  Noriki Ito ,  Yuzo Matsumoto ,  Masaharu Asano ,  Toichi Takenaka

IPC分类号： A61K31/4427 ,  A61K31/455 ,  A61P3/00 ,  A61P3/14 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  C07D211/90 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D211/90

摘要： Dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The compounds have the formula ##STR1## wherein A represents a straight or branched carbon chain alkylene group having 1 to 10 carbon atoms which may be interrupted by an oxygen atom(s); R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group; R.sup.2 represents an amino group, ##STR2## R.sup.3 represents a straight or branched carbon chain alkyl group having 1 to 10 carbon atoms which may be interrupted by an oxygen atom(s), or ##STR3## R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a trifluoromethyl group, a cyano group, a lower alkyl group, a lower alkoxy group or a lower alkenyloxy group; R.sup.7 represents a hydrogen atom, a cyano group, a halogen atom, a lower alkoxy group or a lower alkanoyl group; R.sup.8 and R.sup.9, which may be the same or different, each represents a lower alkyl group or an aralkyl group; and n represents an integer of 1 to 2: these symbols, hereafter, have the same significances.

摘要翻译： 提供二氢吡啶化合物及其盐，其表现出Ca 2+ +拮抗性和肾上腺素能β受体阻断活性，因此可用于治疗缺血性心脏病和高血压。 化合物具有式（I）的化合物，其中A表示可被氧原子间隔的具有1-10个碳原子的直链或支链碳链亚烷基; R 1和R 4可以相同或不同，各自表示低级烷基; R 2表示氨基，R 3表示可被氧原子间隔的具有1〜10个碳原子的直链或支链碳链烷基，或者R 5和R 6 可以相同或不同，分别表示氢原子，硝基，卤素原子，三氟甲基，氰基，低级烷基，低级烷氧基或低级链烯氧基。 R7表示氢原子，氰基，卤素原子，低级烷氧基或低级烷酰基; R 8和R 9可以相同或不同，各自表示低级烷基或芳烷基; n表示1〜2的整数，以下，符号相同。

公开(公告)号：US5420126A

公开(公告)日：1995-05-30

申请号：US982034

申请日：1992-11-24

申请人： Yuzo Matsumoto ,  Ryuji Tsuzuki ,  Akira Matsuhisa ,  Kazuhisa Takayama ,  Wataru Uchida ,  Masaharu Asano ,  Isao Yanagisawa ,  Toru Yoden

发明人： Yuzo Matsumoto ,  Ryuji Tsuzuki ,  Akira Matsuhisa ,  Kazuhisa Takayama ,  Wataru Uchida ,  Masaharu Asano ,  Isao Yanagisawa ,  Toru Yoden

IPC分类号： C07D265/36 ,  C07D413/04 ,  C07D413/06 ,  C07D273/01 ,  C07D413/02

CPC分类号： C07D413/04 ,  C07D265/36 ,  C07D413/06

摘要： Novel benzoxazine derivatives of the formula (I): ##STR1## are provided as well as their pharmaceutically acceptable salts and a method for their use as potassium channel activating agents 2-(3,4-Dihydro-2, 2-dimethyl-6-phenylsulfonyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide is illustrative of a benzoxazine derivative of formula (I). Also provided are intermediate compounds such as those of formula (II): ##STR2##

摘要翻译： 提供了式（I）：新颖的（I）的苯并恶嗪衍生物：其中药学上可接受的盐及其作为钾通道活化剂的方法2-（3,4-二氢-2,2-二甲基 -6-苯基磺酰基-2H-1,4-苯并恶嗪-4-基）吡啶N-氧化物是式（I）的苯并恶嗪衍生物的说明。 还提供了中间体化合物，例如式（II）的那些：（II）

公开(公告)号：US4843085A

公开(公告)日：1989-06-27

申请号：US212929

申请日：1988-06-29

申请人： Takashi Fujikura ,  Yuzo Matsumoto ,  Masharu Asano

发明人： Takashi Fujikura ,  Yuzo Matsumoto ,  Masharu Asano

IPC分类号： C07D213/80

CPC分类号： C07D213/80

摘要： The present invention provides pyridine derivatives of following general formula (I) or a physiologically acceptable acid addition salt thereof: ##STR1## wherein R.sub.1 is a hydrogen atom or a hydroxy group, R.sub.2 and R.sub.3, which may be the same or different, each is a lower alkyl group, and n is an integer of 1 to 6. The invention also provides for producing the pyridine derivative and pharmaceutical compositions containing the same. The compounds (I) possess anti-arrhythmic activity.

公开(公告)号：US4782160A

公开(公告)日：1988-11-01

申请号：US130023

申请日：1987-12-08

申请人： Takashi Fujikura ,  Yuzo Matsumoto

发明人： Takashi Fujikura ,  Yuzo Matsumoto

IPC分类号： C07D211/90

CPC分类号： C07D211/90

摘要： A 1,4-dihydropyridine derivative represented by general formula (I): ##STR1## wherein: R.sup.1 and R.sup.2 : which may be the same or different, each represents an alkyl group which may be intervened by an oxygen atom, a cycloalkyl-substituted lower alkyl group or a halogen-substituted lower alkyl group;R.sup.3 and R.sup.4 : which may be the same or different, each represents a lower alkyl group;R.sup.5 and R.sup.6 : which may be the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group or a lower alkylsulfinyl group;R.sup.7 : hydrogen atom or a lower alkyl group;R.sup.8 : a lower alkyl group; a hydroxy-lower alkyl group, an aralkyl group, an aryl group, a lower acyl group, a lower alkylsulfonyl group or an aryloxy-lower alkyl group, an aryloxy-lower alkoxy group, provided that R.sup.7 and R.sup.8 may be combined together with a nitrogen atom(s) to form a pyrrole ring, a piperidine ring, a morpholine ring or a piperadine ring or azepine ring which may be substituted with a lower alkyl group or an aralkyl group;A: an alkylene group, an alkenylene group or an alkynylene group; and,Y: an oxygen atom or a sulfur atom;or a salt thereof.

公开(公告)号：US5039674A

公开(公告)日：1991-08-13

申请号：US463842

申请日：1990-01-12

申请人： Takashi Fujikura ,  Yuzo Matsumoto

发明人： Takashi Fujikura ,  Yuzo Matsumoto

IPC分类号： C07D211/90

CPC分类号： C07D211/90

摘要： Novel 1,4-dihydropyridine derivatives and salts thereof are provided, which can be represented by the formula ##STR1## wherein, Y represents an oxygen atom or a sulfur atom; A represents an alkylene group, an alkenylene group or an alkynylene group; and R.sup.7 and R.sup.8 can represent individual groups or may be combined together with a nitrogen atom(s) to form a pyrrole ring, a piperidine ring, a morpholine ring or a piperazine ring or azepine ring which may be substituted with a lower alkyl group or an aralkyl group. Pharmaceutical compositions containing the derivatives and their use for imparting calcium antagonistic activity are also provided.

公开(公告)号：US08272634B2

公开(公告)日：2012-09-25

申请号：US12891170

申请日：2010-09-27

申请人： Yasuo Fukatsu ,  Tsuyoshi Moriyama ,  Yuzo Matsumoto

发明人： Yasuo Fukatsu ,  Tsuyoshi Moriyama ,  Yuzo Matsumoto

IPC分类号： B65H3/14

CPC分类号： B65H3/128 ,  B65H1/14 ,  B65H3/48 ,  B65H2405/15 ,  B65H2511/20 ,  B65H2511/222 ,  B65H2511/40 ,  B65H2801/06 ,  B65H2220/02 ,  B65H2220/11 ,  B65H2220/03

摘要： There is provided a sheet feeding device in which a sheet is discriminated at preliminary loosening before feeding, and is set to be controlled according to the type of the sheet by a simple configuration without requiring a special configuration. In the sheet feeding device in which air is blown onto a sheet stack, and a sheet floating at the uppermost level by the blowing is absorbed and conveyed, a sheet type is discriminated, based on a moving amount of the tray, at preliminary loosening before sheet feeding after setting the sheet in a tray.

摘要翻译： 提供了一种片材进给装置，其中在进给之前初步松动地识别片材，并且通过简单的构造将其设置为根据片材的类型进行控制，而不需要特殊的构造。 在将空气吹到片材堆叠上的片材供给装置中，通过吹送而浮动在最上层的片材被吸收并输送，基于托盘的移动量，在预先松开之前判别片材类型 将纸张放入纸盘后进行送纸。

公开(公告)号：US07813660B2

公开(公告)日：2010-10-12

申请号：US11859075

申请日：2007-09-21

申请人： Katsumi Takahashi ,  Yuichiro Maeda ,  Yushi Oka ,  Kenji Kuroki ,  Yuzo Matsumoto ,  Kazunori Togashi ,  Takuya Kawamura

发明人： Katsumi Takahashi ,  Yuichiro Maeda ,  Yushi Oka ,  Kenji Kuroki ,  Yuzo Matsumoto ,  Kazunori Togashi ,  Takuya Kawamura

IPC分类号： G03G15/00

CPC分类号： G03G15/5062 ,  G03G15/2039 ,  G03G15/6564 ,  G03G2215/00067 ,  G03G2215/00569 ,  G03G2215/00599

摘要： An image forming apparatus forms a toner image onto sheets at the first feeding interval on a photoconductor or intermediate transfer member and, if the temperature of a fixing unit falls outside a set temperature range, the sheet layout is changed to a feeding interval wider than the first feeding interval. Adjustment processing is performed based on the image forming condition so that the feeding interval is changed to a wider one in the feeding interval changing step during image formation and it is determined in the determination step to perform adjustment processing, toner patch images are formed in an area where no toner image is formed on the photoconductor or intermediate transfer member . The adjustment processing is performed based on reading toner patch images.

摘要翻译： 图像形成装置在光电导体或中间转印构件上以第一馈送间隔在片材上形成调色剂图像，并且如果定影单元的温度落在设定温度范围之外，则将片材布局改变为比 第一次喂食间隔。 基于图像形成条件进行调整处理，使得在图像形成期间的馈送间隔改变步骤中将馈送间隔变更到更宽的位置，并且在确定步骤中确定执行调整处理，调色剂片图像形成在 在感光体或中间转印部件上不形成调色剂图像的区域。 基于读取调色剂补片图像进行调整处理。

公开(公告)号：US07538315B2

公开(公告)日：2009-05-26

申请号：US11466094

申请日：2006-08-21

申请人： Yuzo Matsumoto

发明人： Yuzo Matsumoto

IPC分类号： G06F7/00 ,  H01J5/16

CPC分类号： H04N1/32459 ,  H04N1/0473 ,  H04N1/1135 ,  H04N1/32358 ,  H04N2201/0468 ,  H04N2201/0471 ,  H04N2201/04729 ,  H04N2201/04731 ,  H04N2201/04734 ,  H04N2201/04744 ,  H04N2201/04786 ,  H04N2201/04787 ,  H04N2201/04789 ,  H04N2201/04791 ,  H04N2201/04796

摘要： This invention makes it possible to prevent any uneven density and degradation in resolution in reciprocal laser scanning using a movable mirror. An image forming apparatus forms an image on a photosensitive member by scanning the photosensitive member with a laser beam reflected by a movable mirror with reciprocating the movable mirror whose rotation angle is changeable in accordance with an electrical signal. The apparatus detects the rotation direction of the movable mirror, and weights, on the basis of the rotation direction, image data of two lines along the sub-scanning direction in correspondence with the ratio of the scanning length after the start of laser write for a line of laser scanning to compensate the image to be formed using the movable mirror.

摘要翻译： 本发明可以防止使用可移动反射镜的相互激光扫描中的不均匀浓度和分辨率的劣化。 图像形成装置通过用可移动反射镜反射的激光束扫描感光部件，使感光部件的旋转角度根据电信号变化而使可动镜反复往复而形成感光部件上的图像。 该装置检测可移动反射镜的旋转方向，并且基于旋转方向，对应于激光写入开始后的扫描长度的比例，沿着副扫描方向对两条线的图像数据进行加权 激光扫描线来补偿使用可移动镜形成的图像。