公开(公告)号：US08809542B2

公开(公告)日：2014-08-19

申请号：US13904609

申请日：2013-05-29

申请人： Takeda Pharmaceutical Company Limited

发明人： Keiji Kamiyama ,  Hideo Hashimoto

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  A61K31/4439

摘要： A sodium salt, magnesium salt, lithium salt, potassium salt, calcium salt or barium salt of (R)-2 -[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2 -pyridinyl]methyl]sulfinyl]-1H-benzimidazole, and a pharmaceutical composition comprising the salt. The novel salt is useful as an excellent antiulcer agent.

摘要翻译： （R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]苯甲酸钠盐，镁盐，锂盐，钾盐，钙盐或钡盐， 亚磺酰基] -1H-苯并咪唑，以及包含该盐的药物组合物。 该新型盐作为优良的抗溃疡剂是有用的。

公开(公告)号：US09265730B2

公开(公告)日：2016-02-23

申请号：US14194050

申请日：2014-02-28

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Muneo Nonomura ,  Hiroki Ito ,  Hideo Hashimoto ,  Tadashi Urai

IPC分类号： A61K9/16 ,  A61K9/24 ,  A61K9/48 ,  A61K31/4439 ,  A61K47/02

CPC分类号： A61K9/1676 ,  A61K9/209 ,  A61K9/4808 ,  A61K31/4439 ,  A61K47/02

摘要： It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.