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公开(公告)号：US09241945B2
公开(公告)日：2016-01-26
申请号：US14361554
申请日：2012-11-29
发明人： Tetsuya Kawano , Yasushi Mima , Yumiko Ishii
IPC分类号： A61K9/16 , A61K9/28 , A61K9/32 , A01N43/00 , A61K31/616 , A61K9/24 , A61K31/4439 , A61K45/06 , A61K9/20 , A61K9/50
摘要： Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.
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公开(公告)号：US10004691B2
公开(公告)日：2018-06-26
申请号：US14891930
申请日：2014-05-20
发明人： Tetsuya Kawano , Yumiko Ishii
IPC分类号： A61K9/20 , A61K9/00 , A61K31/4439 , A61K31/616 , A61K9/50
CPC分类号： A61K9/2081 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/4439 , A61K31/616 , A61K2300/00
摘要： Provided is an orally disintegrating tablet which shows high stability of the active ingredients (acetylsalicylic acid and PPI), and expresses the pharmacological effects of the active ingredients stably and rapidly after administration. A multiple-unit type orally disintegrating tablet containing enteric-coated micro granules containing acetylsalicylic acid, enteric-coated micro granules containing a proton pump inhibitor, and an additive, wherein an enteric coating layer of the enteric-coated micro granules containing acetylsalicylic acid contains an aqueous enteric polymer base and a sustained-release base.
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公开(公告)号：US09907789B2
公开(公告)日：2018-03-06
申请号：US14352785
申请日：2012-10-19
发明人： Yutaka Tanoue , Yusuke Murakawa , Yumiko Ishii , Kaoru Takenaka
IPC分类号： A61K31/4439 , A61K9/20
CPC分类号： A61K31/4439 , A61K9/2018 , A61K9/2031 , A61K9/2054
摘要： Provided is a sustained-release preparation containing pioglitazone or a salt thereof as an active ingredient and showing superior sustainability. A sustained-release preparation containing pioglitazone or a salt thereof, which shows a dissolution ratio of pioglitazone of average 25-58% at the 2-hour time point, and average 60-100% at the 4-hour time point, in a dissolution test according to the 50 rpm USP Paddle Method and using pH 2.0 KCl/HCl buffer at 37° C. as a test solution.
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公开(公告)号：US20140335181A1
公开(公告)日：2014-11-13
申请号：US14361554
申请日：2012-11-29
发明人： Tetsuya Kawano , Yasushi Mima , Yumiko Ishii
IPC分类号： A61K31/616 , A61K9/24 , A61K9/20 , A61K31/4439 , A61K9/28
CPC分类号： A61K9/209 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2886 , A61K9/5026 , A61K9/5078 , A61K31/4439 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.
摘要翻译： 本发明提供了稳定且快速地表达给药后的活性成分的药理作用的活性成分（质子泵抑制剂，乙酰水杨酸）的高稳定性的干燥包衣片剂。 一种具有内芯和外层的干燥包衣片，其中，所述内芯是含有乙酰水杨酸的肠溶片，外层含有含有质子泵抑制剂的肠溶微粒。
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公开(公告)号：US20140248362A1
公开(公告)日：2014-09-04
申请号：US14352785
申请日：2012-10-19
发明人： Yutaka Tanoue , Yusuke Murakawa , Yumiko Ishii , Kaoru Takenaka
IPC分类号： A61K31/4439 , A61K9/20
CPC分类号： A61K31/4439 , A61K9/2018 , A61K9/2031 , A61K9/2054
摘要： Provided is a sustained-release preparation containing pioglitazone or a salt thereof as an active ingredient and showing superior sustainability. A sustained-release preparation containing pioglitazone or a salt thereof, which shows a dissolution ratio of pioglitazone of average 25-58% at the 2-hour time point, and average 60-100% at the 4-hour time point, in a dissolution test according to the 50 rpm USP Paddle Method and using pH 2.0 KCl/HCl buffer at 37° C. as a test solution.
摘要翻译： 本发明提供含有吡格列酮或其盐作为活性成分并显示出优异的可持续性的缓释制剂。 一种含有吡格列酮或其盐的持续释放制剂，其在2小时时间点显示吡格列酮的平均25-58％的溶解比，在4小时时间点平均为60-100％ 根据50rpm USP桨法测试，并在37℃下使用pH2.0KCl / HCl缓冲液作为测试溶液。
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公开(公告)号：US10238605B2
公开(公告)日：2019-03-26
申请号：US15226612
申请日：2016-08-02
发明人： Tetsuya Kawano , Yasushi Mima , Yumiko Ishii
IPC分类号： A61K9/16 , A61K9/28 , A61K9/32 , A01N43/00 , A61K9/24 , A61K9/50 , A61K31/4439 , A61K45/06 , A61K31/616 , A61K9/20
摘要： Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.
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公开(公告)号：US09433632B2
公开(公告)日：2016-09-06
申请号：US14361554
申请日：2012-11-29
发明人： Tetsuya Kawano , Yasushi Mima , Yumiko Ishii
IPC分类号： A61K9/16 , A61K9/28 , A61K9/32 , A01N43/00 , A61K31/616 , A61K9/24 , A61K31/4439 , A61K45/06 , A61K9/20 , A61K9/50
CPC分类号： A61K9/209 , A61K9/2054 , A61K9/2095 , A61K9/2846 , A61K9/2886 , A61K9/5026 , A61K9/5078 , A61K31/4439 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.
摘要翻译： 本发明提供了稳定且快速地表达给药后的活性成分的药理作用的活性成分（质子泵抑制剂，乙酰水杨酸）的高稳定性的干燥包衣片剂。 一种具有内芯和外层的干燥包衣片，其中，所述内芯是含有乙酰水杨酸的肠溶片，外层含有含有质子泵抑制剂的肠溶微粒。
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