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公开(公告)号:US20220332800A1
公开(公告)日:2022-10-20
申请号:US17295770
申请日:2019-09-20
发明人: Subash C. DAS , Isamu TSUJI , Jill A. LIVENGOOD , Hansi DEAN
IPC分类号: C07K16/10 , A61K39/42 , A61K45/06 , G01N33/569
摘要: The present invention provides isolated monoclonal antibodies, or antigen-binding portions thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies, or antigen-binding portions thereof, according to the present invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. The antibodies, or antigen-binding portions thereof, according to the present invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.