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公开(公告)号：US20210403879A1
公开(公告)日：2021-12-30
申请号：US16768550
申请日：2018-11-30
发明人： Jill A LIVENGOOD , Holli GIEBLER , Hansi DEAN , Tatsuki SATOU , Raman RAO , Jackie MARKS , Mark LYONS , Asae SHINTANI , James GIFFORD , Nao OGASAWARA , Masafumi MISAKI , Satoshi ADACHI
摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation and to a method for determining the residual formaldehyde content in a pharmaceutical composition comprising an inactivated virus.
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公开(公告)号：US20240230647A9
公开(公告)日：2024-07-11
申请号：US18030647
申请日：2021-10-08
发明人： Hansi DEAN , Eduardo NASCIMENTO
IPC分类号： G01N33/569 , G01N33/58
CPC分类号： G01N33/56983 , G01N33/582 , G01N2333/185 , G01N2469/20
摘要： The invention relates to methods for determining the presence and/or amount of flavivirus-reactive complement-fixing antibodies in a sample from a subject. Further, the invention is related to methods for the concomitant determination of the presence and/or amount of complement-fixing antibodies reactive to different flaviviruses in a sample from a subject. Moreover, the invention is related to in vitro methods for diagnosing a flavivirus infection in a subject. In addition, the present invention also provides kits for carrying out the methods.
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公开(公告)号：US20240133887A1
公开(公告)日：2024-04-25
申请号：US18030647
申请日：2021-10-07
发明人： Hansi DEAN , Eduardo NASCIMENTO
IPC分类号： G01N33/569 , G01N33/58
CPC分类号： G01N33/56983 , G01N33/582 , G01N2333/185 , G01N2469/20
摘要： The invention relates to methods for determining the presence and/or amount of flavivirus-reactive complement-fixing antibodies in a sample from a subject. Further, the invention is related to methods for the concomitant determination of the presence and/or amount of complement-fixing antibodies reactive to different flaviviruses in a sample from a subject. Moreover, the invention is related to in vitro methods for diagnosing a flavivirus infection in a subject. In addition, the present invention also provides kits for carrying out the methods.
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公开(公告)号：US20220357312A1
公开(公告)日：2022-11-10
申请号：US17766038
申请日：2020-10-02
发明人： Isamu TSUJI , Hansi DEAN , Michael EGAN
IPC分类号： G01N33/50 , C07K16/10 , C12N7/00 , C07K14/005
摘要： The present invention relates to methods for determining affinity, binding kinetics and/or concentration of an antibody or of an antibody mixture specific for a virus using virus-like particles (VLPs) and/or live viruses or inactivated viruses attached to biosensors. Further, the present invention relates to the VLPs and live or inactivated viruses attached to biosensors and methods for producing them.
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公开(公告)号：US20210177959A1
公开(公告)日：2021-06-17
申请号：US16761340
申请日：2018-11-05
发明人： Jill A. LIVENGOOD , Holli GIEBLER , Hansi DEAN , Tatsuki SATOU , Raman RAO , Jackie MARKS , Mark LYONS , Asae SHINTANI , Jamie GIFFORD
摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.
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6.发明公开公开(公告)号：US20240142451A1
公开(公告)日：2024-05-02
申请号：US18284987
申请日：2022-03-31
发明人： Isamu TSUJI , Hansi DEAN , Mayuri SHARMA , Christina DEMASO , Michael EGAN , Eduardo NASCIMENTO
IPC分类号： G01N33/569 , G01N33/543
CPC分类号： G01N33/56983 , G01N33/54373 , G01N2333/185 , G01N2469/20 , G01N2470/04
摘要： The present invention relates to a method for characterizing the immune response of a subject to a tetravalent dengue virus composition by performing the method for determining affinity, binding kinetics and/or concentration of an antibody or of an antibody mixture and at least one other method. In a further embodiment, the present invention relates to a method for characterizing the immune response of a subject to a virus-containing vaccine composition by performing a combination of assays. In a further embodiment, the present invention relates to a method for predicting protective efficacy of a dengue vaccine candidate. In another embodiment the present invention relates to a method for preparing a vaccine formulation.
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公开(公告)号：US20230398199A9
公开(公告)日：2023-12-14
申请号：US16768499
申请日：2018-11-30
发明人： Jill A. LIVENGOOD , Hansi DEAN , Htay Htay HAN , Raman RAO , Jackie MARKS , Gary DUBIN , Laurence DE MOERLOOZE , Hetal PATEL , Asae SHINTANI , Holli GIEBLER , James GIFFORD , Mark LYONS , Sushma KOMMAREDDY , Tatsuki SATOU
CPC分类号： A61K39/12 , A61P31/14 , A61K2039/545
摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof
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公开(公告)号：US20220332800A1
公开(公告)日：2022-10-20
申请号：US17295770
申请日：2019-09-20
发明人： Subash C. DAS , Isamu TSUJI , Jill A. LIVENGOOD , Hansi DEAN
IPC分类号： C07K16/10 , A61K39/42 , A61K45/06 , G01N33/569
摘要： The present invention provides isolated monoclonal antibodies, or antigen-binding portions thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies, or antigen-binding portions thereof, according to the present invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. The antibodies, or antigen-binding portions thereof, according to the present invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
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公开(公告)号：US20210177958A1
公开(公告)日：2021-06-17
申请号：US16761329
申请日：2018-11-05
发明人： Jill A LIVENGOOD , Hansi DEAN , Htay Htay HAN , Raman RAO , Jackie MARKS , Gary DUBIN , Laurence DE MOERLOOZE , Hetal PATEL , Sushma KOMMAREDDY
摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.
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10.发明公开公开(公告)号：US20240325518A1
公开(公告)日：2024-10-03
申请号：US18639558
申请日：2024-04-18
发明人： Jill A. LIVENGOOD , Holli GIEBLER , Hansi DEAN , Tatsuki SATOU , Raman RAO , Jackie MARKS , Mark LYONS , Asae SHINTANI , James GIFFORD , Sushma Kommareddy
CPC分类号： A61K39/12 , A61K9/0019 , A61K39/39 , A61P31/14 , C12N7/00 , A61K2039/5252 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , C12N2770/24034 , C12N2770/24071 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , C12N2770/24164
摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.
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