公开(公告)号：US06262227B1

公开(公告)日：2001-07-17

申请号：US09543351

申请日：2000-04-05

申请人： Takeshi Goto ,  Yoshinobu Higashi ,  Tokihiro Yokoi ,  Takashi Fujisawa

发明人： Takeshi Goto ,  Yoshinobu Higashi ,  Tokihiro Yokoi ,  Takashi Fujisawa

IPC分类号： C08F28300

CPC分类号： A61K31/78

摘要： A process produces a cationic polymer having a cholesterol-lowering activity, which the process includes a step for subjecting a water-soluble monomer component essentially including a cationic monomer to aqueous polymerization so that the viscosity of a polymerization reaction solution is 1,000 cps or more and less than 300,000 cps at the point of time when a polymerization rate reaches 90%, a step for continuing the polymerization until the polymerization rate exceeds 95%, a step for ultrafiltrating the obtained aqueous polymer, a step for concentrating the ultrafiltration treated solution under reduced pressure at a temperature of the solution lower than 100° C., and a step for drying the concentrated solution under a specific condition. The production process can attain both the safety as a drug and a satisfactory production efficiency.

摘要翻译： 一种方法产生具有降低胆固醇活性的阳离子聚合物，该方法包括使基本上包含阳离子单体的水溶性单体组分进行水性聚合以使聚合反应溶液的粘度为1,000cps以上的步骤，以及 在聚合速率达到90％的时间点小于30万cps，聚合速率超过95％的步骤，用于超滤所获得的水性聚合物的步骤，将超滤处理溶液浓缩至减少的步骤 在低于100℃的溶液的温度下的压力，以及在特定条件下干燥浓缩溶液的步骤。 生产过程既可以作为药物的安全性又能达到令人满意的生产效率。