公开(公告)号：US08044068B2

公开(公告)日：2011-10-25

申请号：US12296082

申请日：2007-03-30

申请人： Taketoshi Okubo ,  Toshihito Kumagai ,  Takaaki Ishii ,  Toshio Nakamura ,  Kumi Abe ,  Yuri Amada ,  Tomoko Ishizaka ,  Xiang-Min Sun ,  Yoshinori Sekiguchi ,  Shigetada Sasako ,  Takanori Shimizu ,  Takayuki Nagatsuka

发明人： Taketoshi Okubo ,  Toshihito Kumagai ,  Takaaki Ishii ,  Toshio Nakamura ,  Kumi Abe ,  Yuri Amada ,  Tomoko Ishizaka ,  Xiang-Min Sun ,  Yoshinori Sekiguchi ,  Shigetada Sasako ,  Takanori Shimizu ,  Takayuki Nagatsuka

IPC分类号： A61K31/47 ,  C07D453/04

CPC分类号： C07D401/12

摘要： Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.

摘要翻译： 公开了由式[I]表示的氨基吡咯烷化合物或其药学上可接受的盐。 化合物或盐可用作模式障碍如抑郁症，焦虑障碍，厌食症，恶病质，疼痛和药物依赖性的预防/治疗剂，其作用依赖于MC4受体拮抗作用。

公开(公告)号：US20090291940A1

公开(公告)日：2009-11-26

申请号：US12296082

申请日：2007-03-30

申请人： Taketoshi Okubo ,  Toshihito Kumagai ,  Takaaki Ishii ,  Toshio Nakamura ,  Kumi Abe ,  Yuri Amada ,  Tomoko Ishizaka ,  Xiang-Min Sun ,  Yoshinori Sekiguchi ,  Shigetada Sasako ,  Takanori Shimizu ,  Takayuki Nagatsuka

发明人： Taketoshi Okubo ,  Toshihito Kumagai ,  Takaaki Ishii ,  Toshio Nakamura ,  Kumi Abe ,  Yuri Amada ,  Tomoko Ishizaka ,  Xiang-Min Sun ,  Yoshinori Sekiguchi ,  Shigetada Sasako ,  Takanori Shimizu ,  Takayuki Nagatsuka

IPC分类号： A61K31/553 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/517 ,  A61K31/4709 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14

CPC分类号： C07D401/12

摘要： Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.

摘要翻译： 公开了由式[I]表示的氨基吡咯烷化合物或其药学上可接受的盐。 化合物或盐可用作模式障碍如抑郁症，焦虑障碍，厌食症，恶病质，疼痛和药物依赖性的预防/治疗剂，其作用依赖于MC4受体拮抗作用。

公开(公告)号：US08796272B2

公开(公告)日：2014-08-05

申请号：US14000261

申请日：2012-02-21

申请人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

发明人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

IPC分类号： A61K31/50 ,  A61K31/501

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof: The compounds of the present invention are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

摘要翻译： 本发明涉及式[I]的新化合物或其药学上可接受的盐：本发明的化合物可用于预防或治疗诸如精神分裂症，阿尔茨海默氏病，认知障碍，痴呆，焦虑症（例如， 广泛性焦虑症，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，痉挛，震颤，疼痛，帕金森病，注意缺陷多动障碍，双相 紊乱，进食障碍或睡眠障碍，其基于甘氨酸摄取抑制作用。

公开(公告)号：US20120010414A1

公开(公告)日：2012-01-12

申请号：US13257258

申请日：2010-03-19

申请人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

发明人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

IPC分类号： C07D471/04 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14

CPC分类号： C07D471/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑症（广泛性焦虑障碍，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤和睡眠障碍：

公开(公告)号：US08729271B2

公开(公告)日：2014-05-20

申请号：US13823574

申请日：2011-09-16

申请人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

发明人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

IPC分类号： A01N43/40 ,  A61K31/44 ,  A01N43/64 ,  A61K31/41 ,  C07D213/00 ,  C07D401/00 ,  C07D419/00

CPC分类号： C07D405/14 ,  C07D233/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑障碍（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤，疼痛和睡眠障碍：

公开(公告)号：US08623898B2

公开(公告)日：2014-01-07

申请号：US13257258

申请日：2010-03-19

申请人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

发明人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

IPC分类号： C07D471/04 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14 ,  A01N43/64 ,  A01N43/50 ,  A61K31/41

CPC分类号： C07D471/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑症（广泛性焦虑障碍，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤和睡眠障碍：

公开(公告)号：US20130184460A1

公开(公告)日：2013-07-18

申请号：US13823574

申请日：2011-09-16

申请人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

发明人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

IPC分类号： C07D405/14 ,  C07D403/12 ,  C07D401/12

CPC分类号： C07D405/14 ,  C07D233/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑障碍（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤，疼痛和睡眠障碍：

公开(公告)号：US20130331571A1

公开(公告)日：2013-12-12

申请号：US14000261

申请日：2012-02-21

申请人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

发明人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

IPC分类号： C07D401/04 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof: The compounds of the present invention are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

摘要翻译： 本发明涉及式[I]的新化合物或其药学上可接受的盐：本发明的化合物可用于预防或治疗诸如精神分裂症，阿尔茨海默氏病，认知障碍，痴呆，焦虑症（例如， 广泛性焦虑症，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，痉挛，震颤，疼痛，帕金森病，注意缺陷多动障碍，双相 紊乱，进食障碍或睡眠障碍，其基于甘氨酸摄取抑制作用。

公开(公告)号：US20120116095A1

公开(公告)日：2012-05-10

申请号：US13383513

申请日：2010-07-15

申请人： Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Masato Hayashi ,  Yoshihisa Shirasaki ,  Shuji Yamamoto ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

发明人： Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Masato Hayashi ,  Yoshihisa Shirasaki ,  Shuji Yamamoto ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

IPC分类号： C07D249/12 ,  C07D233/14

CPC分类号： C07D249/10

摘要： The present invention aims to provide novel compounds represented by formula [I] or pharmaceutically acceptable salts thereof: which are useful for prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, convulsion, tremor, pain, or sleep disorders, based on their inhibitory effect against glycine uptake.

摘要翻译： 本发明旨在提供由式[I]表示的新化合物或其药学上可接受的盐：其可用于预防或治疗诸如精神分裂症，阿尔茨海默病，认知障碍，痴呆，焦虑症（例如广泛性焦虑症， 基于它们对甘氨酸摄取的抑制效果，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，惊厥，震颤，疼痛或睡眠障碍。