公开(公告)号：US4808613A

公开(公告)日：1989-02-28

申请号：US169785

申请日：1988-03-18

申请人： Takushi Kaneko ,  Henry S. Wong ,  Jacob J. Utzig

发明人： Takushi Kaneko ,  Henry S. Wong ,  Jacob J. Utzig

IPC分类号： C07H19/044 ,  A61K31/40

CPC分类号： C07H19/044

摘要： There are disclosed analogs of the antitumor agent, rebaccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.

摘要翻译： 公开了具有针对哺乳动物，特别是实验动物肿瘤系统的抗肿瘤特性的抗肿瘤剂，雷卡霉素类似物。 本发明化合物是通过首先使雷贝卡霉素与强碱反应得到反应性中间体，然后使反应性中间体与氨基烷基化合物反应而制备的雷贝卡霉素的氨基烷基化衍生物。

公开(公告)号：US4785085A

公开(公告)日：1988-11-15

申请号：US933428

申请日：1986-11-21

申请人： Takushi Kaneko ,  Henry S. Wong ,  Jacob J. Utzig

发明人： Takushi Kaneko ,  Henry S. Wong ,  Jacob J. Utzig

IPC分类号： C07H19/23 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61P35/00 ,  C07H19/044 ,  C07H5/04

CPC分类号： C07H19/044

摘要： There are disclosed analogs of the antitumor agent, rebeccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.

摘要翻译： 公开了具有针对哺乳动物特别是实验动物肿瘤系统的抗肿瘤特性的抗肿瘤剂雷贝卡霉素类似物。 本发明化合物是通过首先使雷贝卡霉素与强碱反应得到反应性中间体，然后使反应性中间体与氨基烷基化合物反应而制备的雷贝卡霉素的氨基烷基化衍生物。