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公开(公告)号:US5576296A
公开(公告)日:1996-11-19
申请号:US468514
申请日:1995-06-06
申请人: Tamas Bartfai , Tomas H okfelt , Ulo Langel , Bo Ahr en , Stefan Lindskog , Silvana Consolo , Tiit Land , Zsuzsanna Wiesenfeld-Hallin
发明人: Tamas Bartfai , Tomas H okfelt , Ulo Langel , Bo Ahr en , Stefan Lindskog , Silvana Consolo , Tiit Land , Zsuzsanna Wiesenfeld-Hallin
IPC分类号: A61K38/00 , C07K7/02 , C07K7/18 , C07K7/22 , C07K14/575 , C07K14/70 , C07K5/00 , C07K7/00 , C07K17/00
摘要: A galanin antagonist which is a galanin receptor ligand is described. New peptides, Galanin (1-12)-Pro-Substance P(5-11), Galanin (1-12)-Pro-Bradykinin(2-9), Galanin (1-12)-Pro-Pro-Pro- (Leu.sup.5 -Enkephalin (5-1), Galanin (1-12)-Pro-Lys(.epsilon.-NH-)Pro-(Leu5-Enkephalin (5-1) and functional analogues and functional derivatives thereof are disclosed. The peptides are used in pharmaceutical preparations to treat a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor.
摘要翻译: 描述了作为甘丙肽受体配体的甘丙肽拮抗剂。 新肽,格拉宁(1-12)-Pro-物质P(5-11),格拉宁(1-12)-Pro缓激肽(2-9),格拉宁(1-12)-Pro-Pro-Pro-( Leu5-脑啡肽(5-1),Galanin(1-12)-Pro-Lys(ε-NH-)Pro-(Leu5-脑啡肽(5-1))及其功能类似物及其功能衍生物, 在药物制剂中治疗依赖甘蓝蛋白受体的甘丙肽的生理功能的哺乳动物中的病症。