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105 条记录 (耗时 0.039 秒)

    Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
    4.
    发明授权
    Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy 有权
    酰胺化肽合成和体内递送的方法：内啡肽-2用于疼痛治疗

    公开(公告)号：US07825231B2

    公开(公告)日：2010-11-02

    申请号：US11445837

    申请日：2006-06-01

    申请人： Darren P. Wolfe ,  Joseph C. Glorioso ,  David J. Fink

    发明人： Darren P. Wolfe ,  Joseph C. Glorioso ,  David J. Fink

    IPC分类号： C07H21/04 ,  A61K31/711 ,  C12N15/12 ,  C12N15/62

    CPC分类号： C07K5/1016 ,  A61K48/005 ,  C07K7/22 ,  C07K14/67 ,  C07K14/695 ,  C07K14/70 ,  C07K2319/50 ,  C07K2319/60 ,  C12N15/86 ,  C12N2710/16643 ,  G01N33/6893 ,  G01N33/9486 ,  G01N2800/2842

    摘要： The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in operable linkage and under control of a promoter. Where the encoded precursor of a carboxy-amidated peptide is an agonist for an opioid receptor, the invention further provides a method of treating neuropathic pain by administering the gene transfer vector comprising such an expression cassette to a patient. The invention also provides a method for detecting a peptide having a desired effect comprising introducing a library of DNA sequences encoding one or more precursors of carboxy-amidated peptides into host cells; expressing the carboxy-amidated peptides encoded in the library to provide expression products; and screening from the polypeptide expression products for the desired effect.

    摘要翻译： 本发明提供了一种表达盒，其包含编码人前脑啡肽的氨基酸1-99的DNA序列，编码侧翼为二碱基切割位点的羧基酰胺化肽的前体的DNA序列和任选的编码标记蛋白的DNA序列（例如增强型 绿色荧光蛋白（GFP））都在可操作的连锁和启动子的控制下。 当羧基酰胺化肽的编码前体是阿片受体的激动剂时，本发明还提供了通过将包含这种表达盒的基因转移载体给予患者来治疗神经性疼痛的方法。 本发明还提供了一种检测具有所需效果的肽的方法，包括将编码羧基酰胺化肽的一种或多种前体的DNA序列文库导入宿主细胞; 表达在文库中编码的羧基酰胺化肽以提供表达产物; 并从多肽表达产物筛选出所需的效果。

    Neo-tryptophan
    5.
    发明授权
    Neo-tryptophan 失效
    新色氨酸

    公开(公告)号：US07642231B2

    公开(公告)日：2010-01-05

    申请号：US11452616

    申请日：2006-06-14

    申请人： Elliott Richelson ,  Bernadette Marie Cusack ,  Yuan-Ping Pang ,  Daniel J. McCormick ,  Abdul Fauq ,  Beth Marie Tyler ,  Mona Boules

    发明人： Elliott Richelson ,  Bernadette Marie Cusack ,  Yuan-Ping Pang ,  Daniel J. McCormick ,  Abdul Fauq ,  Beth Marie Tyler ,  Mona Boules

    IPC分类号： A61K38/02 ,  A61K38/08

    CPC分类号： C07K7/083 ,  A61K38/00 ,  C07D209/08 ,  C07K7/14 ,  C07K7/18 ,  C07K14/70 ,  C07K14/702

    摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.

    摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。

    Neuroprotective iron chelators and pharmaceutical compositions comprising them
    6.
    发明申请
    Neuroprotective iron chelators and pharmaceutical compositions comprising them 有权
    神经保护性铁螯合剂和包含它们的药物组合物

    公开(公告)号：US20060234927A1

    公开(公告)日：2006-10-19

    申请号：US10534357

    申请日：2006-02-21

    申请人： Moussa Youdim ,  Matityahu Fridkin ,  Hailin Zheng ,  Abraham Warshawsky ,  Rivka Warshawsky

    发明人： Moussa Youdim ,  Matityahu Fridkin ,  Hailin Zheng ,  Abraham Warshawsky ,  Rivka Warshawsky

    IPC分类号： A61K38/22 ,  C07K14/575 ,  A61K31/496 ,  A61K31/4709 ,  C07D403/14

    CPC分类号： C07D295/15 ,  A61K38/00 ,  A61K45/06 ,  A61K47/547 ,  C07D213/69 ,  C07D215/26 ,  C07D295/205 ,  C07K7/06 ,  C07K7/22 ,  C07K7/23 ,  C07K14/57563 ,  C07K14/70 ,  Y02A50/411

    摘要： Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, eg. a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, a inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding ageing, and prevention and/or treatment of skin ageing and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety, the neuroprotective function is imparted to the compound e.g. by a neuroprotective peptide, and a combined antiapoptotic and neuroprotective function by a propargyl group.

    摘要翻译： 显示出神经保护和良好转运性质的新型铁螯合剂可用于铁螯合治疗用于治疗与铁过载和氧化应激相关的疾病，病症或病症，例如， 神经变性或脑血管疾病或病症，肿瘤性疾病，血色素沉着病，地中海贫血，心血管疾病，糖尿病，炎性病症，蒽环类心脏毒性，病毒感染，原生动物感染，酵母感染，延迟衰老以及预防和/或治疗 的皮肤老化和皮肤防晒防晒和/或紫外线。 铁螯合剂功能由8-羟基喹啉，羟基吡啶酮或异羟肟酸盐部分提供，神经保护功能被赋予化合物例如 通过神经保护肽，以及由炔丙基组合的抗细胞凋亡和神经保护功能。

    Stable analogs of bioactive peptides containing disulfide linkages
    8.
    发明授权
    Stable analogs of bioactive peptides containing disulfide linkages 失效
    含有二硫键的生物活性肽的稳定类似物

    公开(公告)号：US06664367B1

    公开(公告)日：2003-12-16

    申请号：US08278437

    申请日：1994-07-21

    申请人： Raghavan Rajagopalan ,  Ananthachari Srinivasan ,  Leon R. Lyle

    发明人： Raghavan Rajagopalan ,  Ananthachari Srinivasan ,  Leon R. Lyle

    IPC分类号： C07K1600

    CPC分类号： C07K14/655 ,  C07K1/006 ,  C07K7/16 ,  C07K14/52 ,  C07K14/6555 ,  C07K14/70 ,  Y10S930/28

    摘要： Stable analogs of cyclic peptides containing disulfide linkages are disclosed. The disulfide linkage is modified by one of four methods: (a) sulfide contraction, (b) isosteric substitution, (c) thioketal expansion, or (d) alkylation expansion. In sulfide contraction the disulfide bond (—S—S—) is replaced with a monosulfide bond (—S—) in which a bifunctional effector molecule, such as a ligand or chemotoxic agent, is bound to the new peptide linkage. In isosteric substitution, one sulfur atom is replaced with a carbon atom and at least one of the carbon atoms at the modified site is a bifunctional effector molecule. In thioketal expansion, an alkylidene unit (—CR1C2—) is inserted between the two sulfur atoms. In alkylation expansion, an alkyl moiety of from C2 to C3, is inserted between the two sulfur atoms.

    摘要翻译： 公开了含有二硫键的环肽的稳定类似物。 二硫键通过四种方法之一进行改性：（a）硫化物收缩，（b）等排取代，（c）硫代缩酮扩展或（d）烷基化扩展。 在硫化物收缩中，二硫键（-S-S-）用单硫键（-S-）代替，其中双功能效应分子如配体或化学毒性剂与新的肽键结合。 在等排取代中，一个硫原子被碳原子取代，并且在修饰位点处的至少一个碳原子是双功能效应子分子。 在硫缩酮扩展中，在两个硫原子之间插入亚烷基单元（-CR1C2-）。 在烷基化扩展中，C2至C3的烷基部分插入在两个硫原子之间。

    Compositions for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
    9.
    发明授权
    Compositions for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules 失效
    使用包含在生物相容性免疫隔离胶囊中的遗传改变细胞递送生物活性分子的组合物

    公开(公告)号：US06264941B1

    公开(公告)日：2001-07-24

    申请号：US09236246

    申请日：1999-01-25

    申请人： Edward E. Baetge ,  Joseph P. Hammang ,  Frank T. Gentile ,  Mark D. Lindner ,  Shelley R. Winn ,  Dwaine F. Emerich

    发明人： Edward E. Baetge ,  Joseph P. Hammang ,  Frank T. Gentile ,  Mark D. Lindner ,  Shelley R. Winn ,  Dwaine F. Emerich

    IPC分类号： A61K4800

    CPC分类号： A61K9/0092 ,  A61K9/0024 ,  A61K9/0085 ,  A61K38/00 ,  A61K48/00 ,  C07K14/48 ,  C07K14/70 ,  C12N15/87

    摘要： This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within a mammalian host. The novel capsules of this invention are biocompatible and are easily retrievable. This invention specifically provides improved methods and compositions which utilize cells transfected with recombinant DNA molecules comprising DNA sequences coding for biologically active molecules operatively linked to promoters that are not subject to down regulation in vivo upon implantation into a mammalian host. Furthermore, the methods of this invention allow for the long-term, stable and efficacious delivery of biologically active molecules from living cells to specific sites within a given mammal. In addition, this invention provides a general means for maintaining, for extended periods of time, the in vivo expression of transgenes.

    摘要翻译： 本发明提供改进的装置和方法，用于使用包含基因工程细胞的生物相容性胶囊长期稳定地表达生物活性分子，用于有效递送生物活性分子以实现或增强哺乳动物宿主内的生物学功能。 本发明的新颖胶囊是生物相容的并且易于回收。 本发明具体提供改进的方法和组合物，其利用重组DNA分子转染的细胞，所述重组DNA分子包含编码与植入哺乳动物宿主体内不受体内下调的启动子有效连接的生物活性分子的DNA序列。 此外，本发明的方法允许将生物活性分子从活细胞长期，稳定和有效地递送到给定哺乳动物内的特定位点。 此外，本发明提供了用于长时间维持转基因的体内表达的一般方法。