专利检索 ap:("Tamas Fodor" OR "Laaszlo Dobay" OR "Jaanos Fischer" OR "Bela Stefkoo" OR "Elemeer Ezer" OR "Judit Matuz" OR "Katalin Saghy" OR "Laaszlo Szporny") AND inv:"Laaszlo Dobay" 第 1 页

1.

发明授权
Butenoic acid amides, their salts, and pharmaceutical compositions containing them 失效
标题翻译：丁烯酸酰胺，其盐和含有它们的药物组合物

公开(公告)号：US4923888A

公开(公告)日：1990-05-08

申请号：US248969

申请日：1988-09-26

申请人： Tamas Fodor , Laaszlo Dobay , Jaanos Fischer , Bela Stefkoo , Elemeer Ezer , Judit Matuz , Katalin Saghy , Laaszlo Szporny

发明人： Tamas Fodor , Laaszlo Dobay , Jaanos Fischer , Bela Stefkoo , Elemeer Ezer , Judit Matuz , Katalin Saghy , Laaszlo Szporny

IPC分类号： C07C231/02 , A61K31/195 , A61K31/22 , A61P1/04 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/12 , C07C235/78

CPC分类号： A61K31/195 , C07C233/12 , Y02P20/55

摘要： The present invention relates to novel compounds of the general formula (I), ##STR1## wherein R stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.1-4 acylamino group;R.sub.1 means hydrogen or a carboxyl-protective group; andR.sub.2 represents a --(CH.sub.2).sub.n --CO.sub.2 R.sub.5 group, whereinn is 1, 2, 3 or 4; andR.sub.5 stands for hydrogen or a carboxyl-protective group; orR.sub.2 means a --(CH.sub.2).sub.n --NH.sub.2 group, whereinn is 1, 2, 3 or 4of E and/or Z configurtion as well as their salts.The compounds according to the invention show a cytoprotective effect and promote the healing of the stomach ulcer. Their toxicity is low.