专利检索 ap:("Tammy H. Huang" OR "Sean Stevens" OR "Joel H. Martin" OR "Jeanette L. Fairhurst" OR "Kevin J. Pobursky" OR "Margaret Karow" OR "Joan A. Windsor" OR "Warren R. Mikluka") AND inv:"Joan A. Windsor" 第 1 页

1.

发明授权
High affinity human antibodies to human IL-18 receptor 有权
标题翻译：人类IL-18受体高亲和力抗体

公开(公告)号：US08105805B2

公开(公告)日：2012-01-31

申请号：US13184603

申请日：2011-07-18

申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikluka

发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikluka

IPC分类号： C12N5/10 , C12N15/12 , C12N15/64

CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76

摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.

摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR），29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列，删除或添加。

2.

发明授权
High affinity human antibodies to human IL-18 receptor 有权
标题翻译：人类IL-18受体高亲和力抗体

公开(公告)号：US08003103B2

公开(公告)日：2011-08-23

申请号：US12577788

申请日：2009-10-13

申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka

发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka

IPC分类号： A61K39/395 , C07K16/28

CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76

摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.

摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR），29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列，删除或添加。

3.

发明授权
High affinity human antibodies to human IL-18 receptor 有权
标题翻译：人类IL-18受体高亲和力抗体

公开(公告)号：US07615220B2

公开(公告)日：2009-11-10

申请号：US11784308

申请日：2007-04-06

申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka

发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka

IPC分类号： A61K39/395 , C07K16/28

CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76

摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.

摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离的抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR），29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列，删除或添加。

4.

发明申请
HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-18 RECEPTOR 有权
标题翻译：人类IL-18受体的高亲和力人体抗体

公开(公告)号：US20100034833A1

公开(公告)日：2010-02-11

申请号：US12577788

申请日：2009-10-13

申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka

发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka

IPC分类号： A61K39/395 , C07K16/28

CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76

摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.

摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离的抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR），29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列，删除或添加。

5.

发明授权
High affinity human antibodies to human IL-4 receptor 有权
标题翻译：人类IL-4受体的高亲和力抗体

公开(公告)号：US08338135B2

公开(公告)日：2012-12-25

申请号：US13309594

申请日：2011-12-02

申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

IPC分类号： C12P21/08

CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92

摘要： An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance, is provided.

摘要翻译： 提供了通过表面等离振子共振测量的以小于200pM的亲和常数（KD）结合人白细胞介素-4受体α（hIL-4Rα）的分离的人抗体或其抗原结合片段。

6.

发明申请
HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN IL-4 RECEPTOR 有权
标题翻译：人类IL-4受体的高亲和力人体抗体

公开(公告)号：US20100291107A1

公开(公告)日：2010-11-18

申请号：US12821499

申请日：2010-06-23

申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

IPC分类号： A61K39/395 , A61P17/00

CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92

摘要： The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.

摘要翻译： 本发明提供了治疗一种或多种通过降低白细胞介素-4（IL-4）活性而改善，抑制或改善的疾病或病症的方法。本发明的方法包括向患者施用特异性结合人IL-4受体的抗体或其抗原结合片段。

7.

发明授权
High affinity human antibodies to human IL-4 receptor 有权
标题翻译：人类IL-4受体的高亲和力抗体

公开(公告)号：US07605237B2

公开(公告)日：2009-10-20

申请号：US11906517

申请日：2007-10-02

申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92

摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance.

摘要翻译： 通过表面等离振子共振测量，其具有小于200pM的亲和常数（KD）的人白细胞介素-4受体α（hIL-4Ralpha）的分离的人抗体或其抗体片段。

8.

发明授权
High affinity human antibodies to human IL-4 receptor 有权
标题翻译：人类IL-4受体的高亲和力抗体

公开(公告)号：US07794717B2

公开(公告)日：2010-09-14

申请号：US12554029

申请日：2009-09-04

申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos

IPC分类号： A61K39/00

CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92

摘要： The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.

摘要翻译： 本发明提供了治疗一种或多种通过降低白细胞介素-4（IL-4）活性而改善，抑制或改善的疾病或病症的方法。本发明的方法包括向患者施用特异性结合人IL-4受体的抗体或其抗原结合片段。