公开(公告)号：US20100068198A1

公开(公告)日：2010-03-18

申请号：US12513663

申请日：2006-11-09

申请人： Tatjana Mijatovic ,  Eric Van Quaquebeke ,  Nancy Denève ,  Laurent Van den Hove ,  Francis Darro ,  Robert Kiss

发明人： Tatjana Mijatovic ,  Eric Van Quaquebeke ,  Nancy Denève ,  Laurent Van den Hove ,  Francis Darro ,  Robert Kiss

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K16/18 ,  A61K31/7088 ,  A61P35/00

CPC分类号： C12N15/1137 ,  C12N2310/14 ,  C12Y306/03009

摘要： Targeting of select subunits of the Na+,K+-ATPase is described, and especially the alpha-1 subunit and/or the alpha-3 subunit. Antisense agents, agents capable of causing RNA interference that can reduce the expression of Na+,K+-ATPase, and antibodies and antibody fragments and derivatives specific for Na+,K+-ATPase are useful as reagents and pharmaceutical formulations for the treatment of proliferative diseases, such as tumours and cancers. Methods and kits are also described.

摘要翻译： 描述了Na +，K + -ATP酶的选择亚基的靶向，特别是α-1亚基和/或α-3亚基。 反义剂，能够引起可以降低Na +，K + -ATP酶以及针对Na +，K + -ATP酶特异性的抗体和抗体片段和衍生物的抗体和抗体的RNA干扰的试剂可用作治疗增殖性疾病的试剂和药物制剂，例如 作为肿瘤和癌症。 还描述了方法和试剂盒。