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    Tricyclic compound and medical use thereof
    6.
    发明授权
    Tricyclic compound and medical use thereof 有权
    三环化合物及其医疗用途

    公开(公告)号：US08273761B2

    公开(公告)日：2012-09-25

    申请号：US12448094

    申请日：2007-12-07

    申请人： Osamu Uchikawa ,  Tatsuki Koike ,  Takafumi Takai ,  Yasutaka Hoashi

    发明人： Osamu Uchikawa ,  Tatsuki Koike ,  Takafumi Takai ,  Yasutaka Hoashi

    IPC分类号： C07D491/048 ,  A61K31/4355

    CPC分类号： C07D491/04 ,  C07D491/14

    摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

    摘要翻译： 本发明提供由下式表示的化合物，其中R 1是任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基，R2是 氢原子或任选具有取代基的烃基，R 3是氢原子，卤素原子，任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的巯基， 取代基，Xa〜Xe各自为碳原子或氮原子，m为0〜2，环A〜环C各自为任选具有取代基的环，或其盐，可用作试剂 用于预防或治疗与褪黑素的作用相关的疾病等。

    Tricyclic compound and pharmaceutical use thereof
    8.
    发明授权
    Tricyclic compound and pharmaceutical use thereof 有权
    三环化合物及其药物用途

    公开(公告)号：US08247429B2

    公开(公告)日：2012-08-21

    申请号：US12448366

    申请日：2007-12-27

    申请人： Osamu Uchikawa ,  Tatsuki Koike ,  Takafumi Takai ,  Yasutaka Hoashi

    发明人： Osamu Uchikawa ,  Tatsuki Koike ,  Takafumi Takai ,  Yasutaka Hoashi

    IPC分类号： A61K31/437 ,  A61K31/416 ,  C07D235/02

    CPC分类号： C07D471/04 ,  C07D213/72 ,  C07D231/54 ,  C07D231/56 ,  C07D235/02

    摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa, Xb, Xc and Xd are each a carbon atom or a nitrogen atom, provided that any one or two of Xa, Xb, Xc and Xd is/are nitrogen atom(s), m is 0 to 2, and rings A to C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

    摘要翻译： 本发明提供由下式表示的化合物，其中R 1是任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基，R2是 氢原子或任选具有取代基的烃基，R 3是氢原子，卤素原子，任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的巯基， 取代基Xa，Xb，Xc和Xd各自为碳原子或氮原子，条件是Xa，Xb，Xc和Xd中的任何一个或两个为氮原子，m为0至2，并且 环A至C各自为任选具有取代基的环或其盐，其可用作预防或治疗与褪黑素的作用有关的疾病等。

    BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
    10.
    发明申请
    BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF 有权
    双相化合物及其药物用途

    公开(公告)号：US20100130538A1

    公开(公告)日：2010-05-27

    申请号：US12451090

    申请日：2008-04-25

    申请人： Tatsuki Koike ,  Takafumi Takai ,  Yasutaka Hoashi

    发明人： Tatsuki Koike ,  Takafumi Takai ,  Yasutaka Hoashi

    IPC分类号： A61K31/437 ,  C07D231/56 ,  C07D471/04 ,  C07D277/64 ,  C07D285/06 ,  C07D275/04 ,  A61K31/416 ,  A61K31/428 ,  A61K31/433 ,  A61P43/00

    CPC分类号： C07D231/56 ,  C07D275/04 ,  C07D277/64 ,  C07D285/14 ,  C07D471/04

    摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

    摘要翻译： 本发明提供由下式表示的化合物：其中R 1为任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基; R2是氢原子或任选具有取代基的烃基; Xa和Xb各自为C，N，O或S; Xc和Xd分别为C或N; m为0-2; n为1-3; 环A是任选具有取代基的5元环; 环B是任选具有取代基的6元环; 并且环C是任选具有取代基的3至5元环，条件是当Xa，Xc和Xd各自为C时，则Xb为N或S，或其盐，其可用作 与褪黑素的作用有关的疾病的预防或治疗等。