公开(公告)号：US4804750A

公开(公告)日：1989-02-14

申请号：US940358

申请日：1986-12-11

申请人： Tatsumi Nishimura ,  Eiichi Eto ,  Toyofumi Yamada

发明人： Tatsumi Nishimura ,  Eiichi Eto ,  Toyofumi Yamada

IPC分类号： B01J19/10 ,  C07H1/08 ,  C07H3/00 ,  C07H3/06 ,  C07H5/06 ,  C07H13/06 ,  C08B37/08 ,  C08L1/00

CPC分类号： C07H3/06 ,  C08B37/003

摘要： Tetra-N-acetyl-chitotetraose, penta-N-acetylchitopentaose and hexa-N-acetyl-chitohexaose, ones of the water-soluble chitin-oligomers, may be obtained in improved yields, when finely ground chitin is quickly and intimately mixed with a concentrated hydrohalogenic acid containing a particular proportion of the hydrogen halide per a unit quantity of the chitin under the irradiation with ultrasonic waves and also under the agitation by mechanical stirrer, followed by hydrolyzing the chitin in the resulting homogeneous mixture comprising the chitin and the concentrated hydrohalogenic acid while said homogeneous mixture is further continuously irradiated with the ultrasonic waves and also agitated by the mechanical stirrer. From the aqueous phase of the hydrolyzed reaction mixture are recovered the desired water-soluble chitin-oligomers which are each useful as an immunopotentiating, antitumor agent or antifungal, antibacterial agent.

摘要翻译： 四乙酰基四聚四糖，五-N-乙酰氨基四糖和六-N-乙酰基六氢六糖，其中一种水溶性几丁质 - 低聚物，可以以提高的产率获得，当细磨几丁质与 在超声波照射下，还在机械搅拌器的搅拌下，每单位量的几丁质含有特定比例的卤化氢的浓缩氢卤酸，然后水解所得到的均匀混合物中的几丁质，所述混合物包含壳多糖和浓缩的氢卤素 酸，同时所述均匀混合物用超声波进一步连续照射，并且还通过机械搅拌器搅拌。 从水解的反应混合物的水相中回收所需的水溶性几丁质寡聚体，其各自可用作免疫增强剂，抗肿瘤剂或抗真菌抗菌剂。