公开(公告)号：US5213974A

公开(公告)日：1993-05-25

申请号：US660414

申请日：1991-02-22

申请人： Tatsuo Haneishi ,  Masatoshi Inukai ,  Keiko Shimizu ,  Fujio Isono ,  Yoshiharu Sakaida ,  Takeshi Kinoshita

发明人： Tatsuo Haneishi ,  Masatoshi Inukai ,  Keiko Shimizu ,  Fujio Isono ,  Yoshiharu Sakaida ,  Takeshi Kinoshita

IPC分类号： C12P1/06

CPC分类号： C12P1/06 ,  Y10S435/886

摘要： The process for producing mureidomycin A, B, C or D or a salt thereof by cultivating Streptomyces flavidovirens SANK 60486, FERM BP-1347, in a culture medium therefor and isolating mureidomycin A, B, C or D or a salt thereof from the cultured broth.

摘要翻译： 通过在其培养基中培养黄色链霉菌SANK 60486，FERM BP-1347，生产mureidomycin A，B，C或D或其盐的方法，并从培养的培养基中分离mureidomycin A，B，C或D或其盐 肉汤。

公开(公告)号：US5039663A

公开(公告)日：1991-08-13

申请号：US253450

申请日：1988-10-04

申请人： Tatsuo Haneishi ,  Masatoshi Inukai ,  Keiko Shimizu ,  Fujio Isono ,  Yoshiharu Sakaida ,  Takeshi Kinoshita

发明人： Tatsuo Haneishi ,  Masatoshi Inukai ,  Keiko Shimizu ,  Fujio Isono ,  Yoshiharu Sakaida ,  Takeshi Kinoshita

IPC分类号： C12P1/06

CPC分类号： C12P1/06

摘要： Novel compounds, called mureidomycins A, B, C and D, may be prepared by cultivation of a suitable microorganism of the genus Streptomyces, especially Streptomyces flavidovirens SANK 60486 (FERM P-8636, FERM BP-1347). These represent a wholly new class of antibiotics, which are valuable in the treatment of infections caused by a variety of bacteria, notably of the genus Pseudomonas.

摘要翻译： 称为mureidomycins A，B，C和D的新化合物可以通过培养链霉菌属（Streptomyces），特别是黄色链霉菌（Streptomyces flavidovirens）SANK 60486（FERM P-8636，FERM BP-1347）的合适的微生物来制备。 这些代表了一类全新的抗生素，对于治疗由多种细菌，特别是假单胞菌属引起的感染是有价值的。

公开(公告)号：US5041423A

公开(公告)日：1991-08-20

申请号：US273199

申请日：1988-11-17

申请人： Tatsuo Haneishi ,  Masatoshi Inukai ,  Keiko Shimizu ,  Fujio Isono ,  Yoshiharu Sakaida ,  Takeshi Kinoshita

发明人： Tatsuo Haneishi ,  Masatoshi Inukai ,  Keiko Shimizu ,  Fujio Isono ,  Yoshiharu Sakaida ,  Takeshi Kinoshita

IPC分类号： A61K38/00 ,  C07D405/04 ,  C07D405/14 ,  C07K5/02

CPC分类号： C07D405/04 ,  C07D405/14 ,  C07K5/0217 ,  A61K38/00

摘要： New antibiotics of the mureidomycin group have the formula ##STR1##wherein X represents the group ##STR2##and wherein R represents hydrogen, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one substituent selected from halogen and alkyl groups having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flaviodovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). Alternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formulaR--CHO.